ENESTPath = A Study to Assess the Effect of a Longer Duration of Consolidation Treatment With Nilotinib on TFR in CP CML
Study title
ENESTPath = A Study to Assess the Effect of a Longer Duration of Consolidation Treatment With Nilotinib on TFR in CP CML [Europe]
Scientific title
A Prospective, Randomized, Open Label, Two Arm Phase III Study to Evaluate Treatment Free Remission (TFR) Rate in Patients With Philadelphia-positive CML After Two Different Durations of Consolidation Treatment With Nilotinib 300mg BID (EudraCT 2012-005124-15), ClinicalTrials.govNCT01743989)
Indication and most important inclusion criteria
Chronic myeloid leukemia (CML)
Patients with a confirmed diagnosis of chronic phase Ph+ CML and with previous first-line treatment with imatinib for at least 2 years; patients should have achieved complete cytogenetic response (CCyR), and should have MR <4.0 at study entry.
Short description of intervention
Changing patients with chronic phase CML (MMR / less than MR4.0) from imatinib to nilotinib (randomized over 2 for 3 years) with the aim of stopping nilotinib in patients with a good response (MR4.0 or better).
Type of studyTreatment free remission
Current status
Recruitment completed
The first patients entered the treatment free remission phase in June 2015.
Study sponsor
Novartis Pharma AG
Scientific lead / contact
Luca Dezzani
Angela Pellegrino
Principal investigator
Michele Baccarani
University of Bologna, Italy
Additional information
- Study description in the EU Clinical Trials Register, which is hosted by the European Medicines Agency (EMA)
- Study description in US register ClinicalTrials.gov, a service of the U.S. National Institutes of Health
- Short protocol in Kompetenznetz Leukämien
- ENESTPath Patient Information Brochure
Study centers
Austria
Graz
LKH Graz Med. Universität Klinik
Innsbruck
Universitätsklinik Innsbruck
Linz
Allgem. öffentl. Krankenhaus der Stadt Linz
Linz
Krankenhaus der Barmherzigen Schwestern
Linz
Krankenhaus der Elisabethinen Linz
Rankweil
Landeskrankenhaus Rankweil
Salzburg
LKH Salzburg / Univ.Klinikum der Paracelsus MPU
Wien
Hanusch-Krankenhaus
Wien
Krankenhaus der Stadt Wien-Hietzing
Belgium
Bruxelles
Cliniques Universitaires Saint-Luc
Edegem
U.Z. Antwerpen
Haine-saint-Paul
CH Jolimont-Lobbes
Kortrijk
AZ Groeninge - Campus Maria's voorzienigheid
Liege
Clinique Saint-Joseph
Tournai
CH WAPI - Site Notre Dame
Bulgaria
Pleven
MHAT "Dr. George Stranski"
Plovdiv
Multifunctional Hospital for Active Treatment "St. George"
Sofia
Alexandrovska University Hospital
Sofia
Specialized Hospital for Active Treatment of Haematological
Varna
Multifunctional Hospital for Active Treatment "Sveta Marina"
Czech Republic
Brno – Bohunice
FN Brno - Bohunice
Denmark
Holstebro
Regionshospitalet Vest Holstebro
Finland
HUS Helsinki
Hematologian tutkimusyksikkö
Turku
TYKS
France
Amiens cedex1
CHU d'Amiens - Hôpital Sud
Angers Cedex 1
CHU d'Angers
Argenteuil Cedex
CHU d'Angers
Auch
Centre Hospitalier General D'auch
Avignon cedex 9
Centre Hospitalier d'Avignon
Bayonne cedex
Centre Hospitalier de la Côte Basque
Besancon cedex
CHU Jean Minjoz
Bordeaux
Institut Bergonie
Bordeaux Cedex
Polyclinique Bordeaux Nord
Brest
CHU de Brest - Hôpital Morvan
Brive la Gaillard
Centre Hospitalier de Brive
Caen cedex
Centre Francois Baclesse
Caen cedex
CHU de Caen
Chalon sur Saône
Centre Hospitalier William Morey
Chambéry cedex
Centre Hospitalier de Chambéry
Clermont Ferrand cedex 1
CHU de Clermont-Ferrand - Hôpital d'Estaing
Corbeil Essonnes
Centre Hospitalier Sud Francilien
Créteil
Centre Hospitalier Henri Mondor
Dunkerque
CHU Dunkerque
Grenoble
Hôpital Albert Michallon
La Roche sur Yon cedex 9
CHD Les Oudairies
Le Chesnay
Hôpital A. Mignot
Le Kremlin Bicetre
Hôpital Kremlin Bicetre
Le Mans cedex 09
Centre Hospitalier Le Mans
Libourne
Hopital Robert Boulin
Lille
CHRU Claude Huriez
Lille cedex
Hôpital Saint Vincent
Limoges cedex
Centre Hospitalier de Limoges
Lorient
Centre Hospitalier Bretagne Sud site de Lorient
Lyon Cedex
Centre Léon Bérard
Marseille
AP-HM - Hôpital de la Conception
Marseille Cédex 9
Institut Paoli Calmettes
Metz cedex 03
CHR Metz Thionville
Montpellier cedex 5
CHRU de Montpellier - Hôpital Saint Eloi
Mulhouse cedex
C H de Mulhouse - Hôpital Emile Muller
Nantes
Hopital Hotel Dieu
Nice Cedex
CHU de Nice Hôp. de l'Archet 1
Orleans
CHR Orleans
Paris
Hopital Saint Antoine
Paris Cedex 10
Hôpital Saint Louis
Paris
Hôpital Necker - Enfants Malades
Paris Cedex 13
Groupe Hospitalier Pitie-Salpetriere
Paris Cedex 14
Hôpital Cochin
Perpignan
CH de Perpignan
Pessac
Hôpital du Haut-Lévêque
Pierre-Benite Cédex
Centre Hospitalier Lyon-Sud
Poitiers
CHU Poitiers
Pontoise
Centre Hospitalier Rene Dubos
Pringy cedex
Centre Hospitalier de la Région d'Annecy
Reims
Hôpital Robert Debré
Rennes
CHRU de Rennes
Rouen Cedex 1
Centre Henri Becquerel-CLCC Hte Normandie
Saint Brieuc cedex 1
CH de Saint-Brieuc - Hôpital Yves Le Foll
Saint-Priest-en-Jarez
Institut de Cancérologie Lucien Neuwirth
Strasbourg cedex
HUS - Hôpital Civil
Strasbourg cedex
G H St Vincent-Clinique Ste Anne
Toulouse cedex 9
CHU de Toulouse - Hôpital Purpan
Toulouse cedex 9
Clinique Pasteur
Tours Cedex 9
CHRU de Tours - Hôpital Bretonneau
Valenciennes
Hôpital de Valenciennes
Vandoeuvre Les Nancy
C.H.U. Nancy - Brabois
Vannes
CH Bretagne Atlantique - Hôpital Prosper Chubert
Vichy
Centre hospitalier de Vichy
Germany
Aschaffenburg
Gemeinschaftspraxis
Augsburg
Gemeinschaftspraxis
Aurich
Praxis Reichert
Baden-Baden
Medizinische Klinik
Neben
Bayreuth
Klinikum Bayreuth
Berlin
Charité Berlin Campus Virchow-Klinikum
Berlin
Praxis Josting
Bottrop
Onkologische Schwerpunktpraxis Bottrop
Braunschweig
Städtisches Klinikum Braunschweig
Bremen
Klinikum Bremen Mitte
Chemnitz
Klinikum
Hänel
Donauwörth
Onkologisches Zentrum-MVZ Filiale
Dresden
Praxis Freiberg-Richter
Eisenach
Praxis Blumenstengel
Essen
Univ.-Klinikum Essen
Frankfurt
Onkologische Gem. Praxis
Goch
Wilhelm-Anton-Hospital Goch gGmbH
Goslar
Onkologische Kooperation Harz
Gütersloh
Städtisches Klinikum Gütersloh
Halle
Praxis
Hamm
Evangelisches Krankenhaus
Lange
Hannover
Königsmann
Ingolstadt
Praxis
Karlsruhe
Städtisches Klinikum Karlsruhe
Kassel
Gemeinschaftspraxis
Kiel
Universität Kiel - Molekulargenetische Medizinische Klinik
Köln
Gemeinschaftspraxis
Köln
Klinikum der Universität zu Köln
Landshut
Tagesklinik
Vehling-Kaiser
Leipzig
Universität Leipzig
Lübeck
Lübecker Onkologische Schwerpunktpraxis
Magdeburg
Praxis PD
Mainz
Hanusch-Krankenhaus
Mannheim
Universitätsklinikum Mannheim
Marburg
Universitätsklinikum Gießen und Marburg GmbH
Memmingen
Praxis Jäckle
München
Gemeinschaftspraxis
München-Pasing
Praxis Schmidt
Münster
Universitätsklinikum Münster
Schmidt
Nürnberg
Internistische Praxisklinik
Offenburg
Klinikum Offenburg-Ortenau
Osnabrück
Niels-Sensen Kliniken
Wamhoff
Potsdam
Praxis
Rostock
Gemeinschaftspraxis
Rostock
Universitätsmedizin Rostock
Schorndorf
Onkologie Zentrum Bürkle
Schwäbisch-Hall
Diakonie Krankenhaus Schwäbisch-Hall
Stade
MVZ Klinik
Stuttgart
Springer Schwerpunktspraxis Onkologie am Hauptbahnhof
Westerstede
Med. Studiengesellschaft NORD-WEST GmbH
Würzburg
Universitätsklinikum
Goebeler
Greece
Athens
Athens General Hospital Laiko
Athens
General Hospital of Athens "Evangelismos"
Athens
General Hospital of Athens G. Gennimatas
Ioannina
University General Hospital of Ioannina
Patras
University General Hospital of Patras
Thessaloniki
General Hospital of Thessaloniki Papanikolaou
Hungary
Budapest
Egyesitett Szent Istvan-Szent Laszlo Korhaz-Rendelointezet
Debrecen
DEOEC, III Belgyogyaszati Klinika
Gyor
Petz Aladar Megyei Oktato Korhaz
Szedged
Szegedi Tudomanyegyetem
Ireland
Dublin, 8
St James' Hospital
Italy
Alessandria
Az. Osp. SS. Antonio e Biagio e C. Arrigo
Ancona
AOU Osp. Riuniti Umberto I-GM Lancisi-G.Salesi-Univ.Studi
Avellino
Az. Ospedaliera S.G. Moscati
Bari
Az.Osp.Univ.Consorziale Policlin.di Bari Univ.degli Studi
Bergamo
Azienda Ospedaliera Papa Giovanni XXIII
Bologna
Az.Osp.di Bologna Policl.S.Orsola-Malpighi Univ.degli Studi
Bolzano
Az. San. dell'Alto Adige - Comprensorio Sanitario di Bolzano
Brescia
Az. Osp. Spedali Civili di Brescia Univ.degli Studi
Cagliari
Ospedale Oncologico A. Businco
Presidio Ospedaliero Roberto Binaghi - ASL Cagliari
Catania
Presidio Ospedaliero Ferrarotto-AOU Policlinico-V Emanuele
Presidio Ospedaliero Garibaldi - Nesima
Catanzaro
Azienda Ospedaliera Pugliese-Ciaccio
Cona
Az. Osp-Univ. Ferrara - Arcispedale S.Anna Univ. degli Studi
Cremona
Az. Osp. Istituti Ospitalieri di Cremona P.O. di Cremona
Firenze
Az. Osp.Universit.Careggi-Univ. Studi di Firenze
Foggia
A.O.Ospedali-Un.OO.RR Foggia-Pres.Ospedali Riuniti di Foggia
Genova
IRCCS Az. Osp. Univ. S.Martino-IST Ist. Naz. Ric. Cancro
Lecce
Presidio Ospedaliero Vito Fazzi ASL Lecce
Livorno
Presidio Ospedaliero Livorno - ASL Livorno 6
Messina
Az.Ospe.Universitaria Policlinico G. Martino Univ.di Messina
Milano
Az.Ospedaliera Niguarda Ca' Granda
Fond.IRCCS Ca'Granda Ospedale Maggiore Policlinico Univ.Stud
Ospedale San Raffaele IRCCS S.r.l.
Mirano
Presidio Ospedaliero di Mirano - Azienda ULSS 13
Modena
A.O.Univ.Policl.di Modena Univ.Studi Modena e R.Emilia
Monza
Ospedale San Gerardo
Napoli
Azienda Ospedaliera di Rilievo Nazionale A. Cardarelli
A.Osped.-Universit. Policlinico Federico II Univ.degli Studi
Novara
Az. Osp. Univ.Maggiore della Carità
Orbassano
Az.Sanit.Osp.Univers.S.Luigi Gonzaga Orbassano
Padova
Azienda Ospedaliera di Padova Università degli Studi
Pagani
Presidio Ospedaliero Andrea Tortora - ASL Salerno
Palermo
Az.Osp.Univ.Policlinico P.Giaccone Università Studi Palermo
A.O. Ospedali Riuniti Villa Sofia-Cervello - P.O. Cervello
Casa di Cura di Alta Spec. La Maddalena - Dip. Onc III livel
Parma
Az. Ospedaliero Universitaria di Parma
Pavia
Fodazione IRCCS Policlinico S.Matteo Univ.degli Studi Pavia
Perugia
Osp S. Maria della Misericordia-A.O. Perugia - Univ. Studi
Pesaro
Azienda Ospedaliera Ospedale San Salvatore
Pescara
Presidio Ospedaliero Spirito Santo-AUSL Pescara
Piacenza
Presidio Ospedaliero di Piacenza AUSL Piacenza
Pisa
A.O.Univ.Pisana-Pres.Osp.S.Chiara-Univ.degli Studi
Potenza
Azienda Ospedaliera S. Carlo
Reggio Calabria
A.O. Bianchi Melacrino Morelli - Presidio Ospedali Riuniti
Reggio Emilia
Az.Ospedaliera di Reggio Emilia - Arcispedale S. Maria Nuova
Roma
A.O.Policlinico Umberto I - Università La Sapienza
Ospedale S. Eugenio ASL Roma C
Policlinico A. Gemelli-Università Cattolica del Sacro Cuore
Fondaz.Policlin.Tor Vergata-Univ. degli Studi Tor Vergata
Rossano
Presidio Ospedaliero Nicola Giannattasio
Salerno
Az.Osp.Univ.O.O.R.R. S. Giovanni di Dio e Ruggi d'Aragona
San Giovanni Rotondo
IRCCS Casa Sollievo della Sofferenza
Siena
Az.Osp.-Universitaria Senese Università degli Studi di Siena
Taranto
Stab.Osped. S.Giuseppe Moscati- P.O.Centrale SS.Annunziata
Terni
Azienda Ospedaliera S. Maria di Terni - Univ. Studi Perugia
Torino
AO Città della Salute e della Scienza Torino - P.O.Molinette
Treviso
Pres.Ospedaliero S.Maria di Ca' Foncello
Tricase
A.O.Pia Fondaz.di Culto e Religione Card. G. Panico
Udine
Az.Osped.-Universit.Santa Maria della Misericordia di Udine
Venezia
Ospedale dell'Angelo - Az. ULSS n. 12 Veneziana
Verona
.Osp.Univ.Integrata Verona-Osp.Borgo Roma Univ.degli Studi
Vicenza
Presidio Ospedaliero S.Bortolo ULSS 6 Vicenza
Norway
Bergen
Haukeland University Hospital
Oslo
Rikshospitalet
Portugal
Lisboa
Hospital de Santa Maria
Lisboa
Instituto Português de Oncologia de Lisboa
Porto
Instituto Portugues de Oncologia do Porto
Porto
Centro Hospitalar de São João, E.P.E.
Porto
Centro Hospitalar do Porto, EPE - HSA
Slovakia
Bratislava
Fakultna Nemocnica Poliklinikou
Bratislava
Narodny onkologicky ustav - oddelenie klinickej onkologie
Martin
Martinsk.Fakultna Nemocnica
Spain
Alcala de Henares
Hospital Principa de Asturias
Alicante
Hospital General Universitario de Alicante
Alzira
Hospital de la Ribera
Badalona
Hospital Universitario Germans Trias i Pujol
Baracaldo
Hospital de Cruces
Barcelona
Hospital Clinic l Provincial De Barcelona
Barcelona
Hospital de la Santa Creu i Sant Pau
Barcelona
Hospital del Mar
Barcelona
Hospital Vall D'Hebron
Bilbao
Hospital de Basurto
Caceres
San Pedro De Alcantara Hospital
Cordoba
Hospital Reina Sofia
El Palmar
Hospital Universitario Virgen Arrixaca
Gasteiz
Hospital Txagorritxu
Girona
Hospital Universitario de Girona Dr. Josep Trueta
Granada
Hospital Virgen de las Nieves
Hospitalet de LLobregat
Hospital Durans I Reynals-ICO
Jaen
Complejo Hospitalario de Jaen
La Coruna
Complejo Uni. Hosp. A Coruna ( antes Hospital Juan Canalejo)
León
Hospital Virgen Blanca de León
Madrid
Fundacion Jimenez Diaz
Madrid
Hospital Clinico San Carlos
Madrid
Hospital 12 de Octubre
Madrid
Hospital Gregorio Marañon
Madrid
Hospital Infanta Leonor
Madrid
Hospital La Paz
Madrid
Hospital Ramon Y Cajal
Madrid
Hospital Universitario de la Princesa
Majadanonda
Hospital Puerta de Hierro
Málaga
Hospital Carlos Haya
Mallorca
Hospital Son Llatzer
Murcia
Hospital Morales Meseguer
Oviedo
Hospital General de Asturias
Palma de Mallorca
Hospital Son Espases
Pamplona
Complejo Hospitalario de Navarra
Pontevedra
Hospital Provincial de Pontevedra
Sabadell
Corporacio Sanitaria Parc Tauli Sabadell
Salamanca
Hospital Universitario de Salamanca
San Sebastian
Hospital de Donostia
Santa Cruz de Tenerife
Hospital Ntra. Sra. Candelaria
Santander
Hospital Universitario Marques de Valdecilla
Santiago de Compostela
Hospital Clinico Universitario Santiago de Compostela
Sevilla
Hospital Universitario Virgen Marcarena
Sevilla
Hospital Virgen del Rocio
Tarragona
Hospital Universitario Joan XXIII
Valencia
Hospital Universitario i Politecnic La Fe
Valladolid
Hospital Clinico Universitario de Valladolid
Vigo
Hospital Xeral de Vigo
Zaragoza
Hospital Universitario Miguel Servet
Sweden
Göteborg
Sahlgrenska Universitetssjukhuset
Lund
Skånes Universitetssjukhus
Stockholm
Karolinska Universitetssjukhuset Solna
UK
London
Hammersmith Hospital London
Barts and the London NHS Trust
Edinburgh
Western General Hospital
Manchester
University Hospital of South Manchester
East Yorkshire
Castle Hill Hospital
Oldham
Royal Oldham Hospital
Salford
Salford Royal Hospital
CML-Paed II = Registration of Children with CML and Treatment with Imatinib [Germany]
Study title
CML-Paed II = Registration of Children awith CML and Treatment with Imatinib
Scientific title
Protocol for standardized diagnostic procedures, registration, and treatment recommendations in children and adolescents with Philadelphia chromosome-positive chronic myeloid leukemia (CML) (EudraCT 2007-001339-69, ClinicalTrials.gov NCT00445822)
Indication and most important inclusion criteria
Newly diagnosed Ph+ or BCR-ABL-positive CML in children and adolescents under the age of 18 years. Potential study participants have not been pretreated with interferon alpha or any other cytostatic drug with the exception of hydroxyurea or anagrelide (Note: anagrelide is not approved in Germany for the treatment of CML). However, these patients may be registered as observational patients.
Short description of intervention
The objective of this study is to assess the antileukemic activity of imatinib in children and adolescents with newly diagnosed Ph+ or BCR-ABL-CML over a treatment period of two years. Primary endpoint is the rate of haematological, cytogenetical and molecular remissions.
Type of study
Paediatric trial
Current status
No longer recruiting
Study sponsor
Universität Dresden, Germany
Scientific lead / contact
Prof. Dr. Meinolf Suttorp
Principal investigator
Prof. Dr. Meinolf Suttorp
Universitätsklinikum Dresden
Bereich pädiatrische Hämatologie und Onkologie
Study centers / principal investigators
Centers of paediatric haematology oncology within the network of the Society for Paediatric Oncology and Haematology (GPOH) or of the national societies of Paediatric Oncology and Haematology
Additional information
Study description in ClinicalTrials.gov
Study protocol in English, Patient information in Germany, Fachinformation Glivec in German
ENESTop = A clinical research study evaluating the possibility to stop the drug nilotinib in chronic myeloid leukemia (CML) patients who have very small amount of leukemia cells remaining after nilotinib treatment
Study title
ENESTop = A clinical research study evaluating the possibility to stop the drug nilotinib in chronic myeloid leukemia (CML) patients who have very small amount of leukemia cells remaining after nilotinib treatment
Scientific title
A phase II, single arm, open label study of treatment-free remission after achieving sustained MR4.5 on nilotinib (EudraCT 2012-003186-18; ClinicalTrials.gov NCT01698905)
Indication and most important inclusion criteria
Chronic myeloid leukemia (CML) chronic phase patients.
Potential participants should have been diagnosed with CML and should have received first-line treatment with imatinib, then switched to nilotinib for at least 2 years prior to study entry with the combined time on imatinib and nilotinib being at least 3 years. Patients must not have documented MR4.5 at the time of switch to nilotinib, and should have achieved MR4.5 on nilotinib.
Short description of intervention
To stop nilotinib treatment in CML-CP patients (who started treatment with ≥ 4 weeks of imatinib, then switched to nilotinib for a minimum of 2 years (with minimum combined duration on imatinib and nilotinib ≥ 3 years), and achieved MR4.5 on nilotinib) who maintained MR4.5 during the 1 year nilotinib treatment on study.
Type of study
Treatment free remission trial
Current status
Recruitment completed
Study sponsor
Novartis Pharma AG
Scientific lead / contact
Yu Jin
Clinical Trial Head
Yu-1.jin@novartis.com
Rafik Fellague-Chebra
Medical Director
rafik.fellague-chebra@novartis.com
Principal investigator
Tim Hughes
Francois-Xavier Mahon
Dong-Wook Kim
Additional information
Study description in the EU Clinical Trials Register which is hosted by the European Medicines Agency (EMA)
Study description in the US register ClinicalTrials.gov, a service of the U.S. National Institutes of Health
"ENESTop brochure: Answers to frequently asked questions patients may have about the study of and treatment with nilotinib"
"ENESTop brochure "Molecular response: a measure of treatment success in Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML)"
Study centers
Argentina
Buenos Aires
Fundaleu
Buenos Aires
Hospital Jose Maria Ramos Mejia
Australia
Box Hill
Box Hill Hospital
Adelaide
Royal Adelaide Hospital
St. Leonards
Royal North Shore Hospital
Belgium
Antwerp
ZNA Stuivenberg Hematology/Oncology
Gent
Universitair Ziekenhuis Gent
Haine-saint-Paul
Jolimont
Brazil
Campinas
Universidade de Campinas
Belo Horizonte
Hospital das Clínicas de Belo Horizonte – UFMG
Goiania
Hospital Universitário de Gôiania
Curitiba
Hospital Santa Casa de Curitiba PUCPR
Porto Alegre
Hospital de Clínicas de Porto Alegre
Rio de Janeiro
Instituto Estadual de Hematologia Arthur de Siqueira Cavalca
São Paulo
Hospital das clinicas da Faculdade de Medicina da USP
São Paulo
Irmandade de Santa Casa de Misericordia de Sao Paulo
Rio de Janeiro
Instituo Nacional do Cancer
São Paulo
Casa de Saude Santa Marcelina
Canada
Toronto
Princess Margaret Hospital
Hamilton
The Juravinski Cancer Clinic
Montreal
Hopital Maisonneuve-Rosemont
Québec
Hopital de I'Enfant Jesus
France
Bordeaux
Institut Bergonie
Pierre-Benite Cédex
Centre Hospitalier Lyon-Sud
Vandoeuvre les Nancy
CHU Brabois
Grenoble Cedex 9
Hopital Albert Michallon
Strasbourg Cedex
GH St. Vincent-Clinique Ste Anne
Germany
Berlin
Charité Universitätsmedizin Berlin
Ulm
Universitätsklinikum Ulm
Potsdam
MVZ für Blut- und Krebserkrankungen Potsdam
Mannheim
Universitätsmedizin Mannheim
Heilbronn
Onkologie Heilbronn
Leipzig
Universitätsklinikum Leipzig
Greece
Heraklion Crete
University General Hospital of Heraklion
Athens
Attikon Univ. Gen. Hospital of Athens
Athens, Neo Faliro
Metropolitan Hospital
Athens – GR
General Hospital of Athens Evangelismos
Larissa
University General Hospital of Larissa
Israel
Ramat Gan
The Chaim Sheba Medical Center
Petach Tikva
Rabin Medical Center
Haifa
Rambam Medical Center
Japan
Akita
Akita University Hospital
Fukuoka-city
Kyushu University Hospital
Nagoya
Aichi Cancer Center Hospital
Aomori
Aomori Prefecture Central Hospital
Kurume
Kurume University Hospital
Narita
Narita Red Cross Hospital
Chiba-city
Chiba University Hospital
Korea, Republic of
Seoul
Seoul St. Mary's Hospital
Mexico
San Luis Potosí
Centro Regional de Enfermedades Oncologicas
México
Instituto Nacional de Cancerologia
Monterrey
Hospital y Clinica OCA
Netherlands
Amsterdam
VUMC Amsterdam
Poland
Krakow
Collegium Medicum Uniwersytetu Jagielonskiego (Krakow)
Gdansk
Uniwersyteckie Centrum Kliniczne Katedra i Klinika Hematolog
Warzawa
Instytut Hematologii i Transfuzjologi (Warszawa)
Russian Federation
Moscow
Hematological Scientific Center of RAMS
St. Petersburg
State Pavlov Medical University
St. Petersburg
Research Institute of Hematology and Blood Transfusion, 16
Singapore
Singapore General Hospital
Spain
Madrid
Hospital Universitario de la Princesa
Sevilla
Hospital Virgen del Rocio
Alicante
Hospital General Universitario de Alicante
Badalona
Hospital Universitario Germans Trias i Pujol
Santander
Hospital Universitario Marques de Valdecilla
Madrid
Hospital Ramon y Cajal
Madrid
Hospital Universitario La Paz
Santa Cruz de Tenerife
Hospital Universitario de Canarias
Tunisia
Tunis
Hôpital Aziza Othmana
United Kingdom
Liverpool
Royal Liverpool University Hospital
Nottingham
Nottingham City Hospital
Bournemouth
Royal Bournemouth Hospital
USA
Los Angeles
USC/Kenneth Norris Comprehensive Cancer Center
Indianapolis
Indiana Blood and Marrow Institute
Duarte
City of Hope National Medical Center
Baltimore
St. Agnes Hospital
Vancouver
Compass Oncology
Galveston
University of TX Medical Branch
BFORE (AV001) = Bosutinib versus Imatinib in Adult Patients with Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia
Study title
BFORE (AV001) = Bosutinib versus Imatinib in Adult Patients with Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia [Africa, Asia, Australia, Europe, North America]
Scientific title
A Multicenter Phase 3 Randomized, Open-Label Study of Bosutinib versus Imatinib in Adult Patients with Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia (EudraCT No. 2013-005101-31, clinicaltrials.gov NCT02130557)
Indication and most important inclusion criteria
Patients 18 years and older with molecular diagnosis of chronic phase CML can be enrolled within 6 months from initial diagnosis. Philadelphia chromosome status will be identified at screening. Both Philadelphia positive (Ph+) and Philadelphia negative (Ph-) patients may be included. Patients should have adequate function of liver, kidney and pancreas and an Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1. Patients should be able to take oral tablets.
Short description of intervention
The aim of the study is to assess how well bosutinib works compared to imatinib in patients with newly diagnosed Philadelphia chromosome positive (Ph+) chronic phase (CP) chronic myelogenous leukemia (CML). The Major Molecular Response (MMR) rate of bosutinib at 12 months will be compared with that of imatinib. All patients will be treated and/or followed for 5 years (240 weeks) after randomization until the study has closed.
Type of study
First line trials
Current status
no longer recruiting
Study sponsor
Pfizer
Scientific lead / contact
Rocco Crescenzo
Principal investigator
Europe:
Prof. Dr. med. Tim H. Brümmendorf
tbruemmendorf@ukaachen.de
USA:
Dr. Jorge Eduardo Cortes, M.D.
Additional information
Study description in the EU Clinical Trials Register, which is hosted by the European Medicines Agency (EMA)
Study description in US register ClinicalTrials.gov, a service of the U.S. National Institutes of Health
Study centers / principal investigators
Australia
Adelaide, SA 5000
275 North Terrace
Tim Hughes
Bedford Park SA 5042
SA Pathology (at Flinders Medical Centre)
David Ross (Contact person: Kayleen Charles)
Kayleen.Charles@health.sa.gov.au
Box Hill, 3128
5 Arnold St
Anthony Schwarer
Frankston, 3199
Frankston Hospital
John Catalano
Kogarah, New South Wales, 2217
St George Hospital
Clinical Trials Unit-Cancer Services, Department of Clinical Haematology,
Dr. Shir-Jing Ho
shir-jing.ho@sesiahs.health.nsw.gov.au
Belgium
Gent, 9000
University Hospital of Gent (UZ Gent)
Prof. Lucien Noens
Leuven, 3000
UZ Leuven, Hematology Department
Prof. Gregor Verhoef
Liège, 4000
Hematology CHU de Liège - Hôpital du Sart-Tilman
Dr. Marie Lejeune
Verviers, 4800
Centre Hospitalier Peltzer La Tourelle (GHPLT) Verviers
Dr. Gaetan Vanstraelen
Canada
Ontario
Barrie, L4M 6M2
Royal Victoria Regional Health Centre
Dr. Rouslan Kotchetkov
Hamilton, L8V 5C2
Brian Leber
Oshawa, L1G 2B9
Durham Region Cancer Centre Lakeridge Health Oshawa
Dr. Ariah Schattner
aschattner@lakeridgehealth.on.ca
Toronto, M5G 2M9
Medical Oncology and Hematology Princess Margaret
Dr. Jeffrey Lipton
New Brunswick
Internal Medicine Department
Moncton Hospital
Moncton, E1C 6Z8
Dr. Nizar Abdel-Samad
Quebec
Montreal, H1T 2M4
Lambert Busque
Quebec City, G1J 1Z4
CHU de Québec - Hôpital de l'Enfant-Jésus
Dr. Robert Delage
Saskatchewan
Saskatoon, S7N 4H4
Dr. Julie Stakiw
Czech Republic
Brno, 625 00
Fakultni Nemocnice Brno
Interni Hematoonkologicka a Onkologicka Klinika
Prof. Jiri Mayer
Hradec Kralove, 500 05
Fakultni Nemocnice Hradec Kralove, IV.
Interni Hematologicka Klinika
Dr. Petra Belohlavkova
Olomouc, 77520
Fakultní nemocnice Olomouc
Hematology - Oncology department
Edgar Faber
Prague, 128 08
Ustav Hematologie a Krevni Transfuze
Dr. Hana Klamova
Prague, 128 08
Vseobecna Fakultni Nemocnice Praha, I. Interni Klinika - Klinika Hematologie
Prof. Marek Trneny
Denmark
Aalborg, 9000
Aalborg University Hospital
Department of Hematology
Marianne Severinsen
Aarhus, 8000 C
Aarhus University Hospital
Department of Hematology
Prof. Jesper Stentoft
Odense, 5000
Odense University Hospital
Department of Hematology
Hanne Vestergaard
Roskilde, 4000
Roskilde Hospital
Department of Hematology
Dr. Lene Udby
Finland
Helsinki, 00029 HUS
M.D. Kimmo Porkka
France
Bordeaux, 33076
Service Oncologie Médicale Institut Bergonié- CRLCC
Dr. Gabriel Etienne
Le Chesnay cedex, 78157
Hôpital Mignot
Service Hematologie
Prof. Dr. med. Philippe Rousselot
Nantes cedex 1, 44093
CHU Nantes
Service Hematologie
Dr. med. Viviane Dubruille
Nice, 6202
Hopital l'Archet 1
Dr. Laurence Legros
Nîmes Cedex 9, 30029
Hématologie Clinique
Groupe Hospitalo-Universitaire Caremeau
Dr. Eric Jourdan
eric.jourdan@chu-nimes.fr
Pierre Benite, 69495
CHU Lyon Sud
Hématologie Prof. Dr. med. Mauricette Michallet
Poitiers, 86021
Haematology University Hospital of Poitiers
Cristina Precupanu
Strasbourg, 67000
Haematology St. Anne
M.D. Frederic Maloisel
Toulouse, 31059
Haematology CHU Purpan
Dr. Francoise Huguet (Dr. Travitian)
huguet.francoise@iuct-oncopole.fr
Germany
Aachen, 52074
Universitätsklinikum Aachen AÖR
Klinik für Onkologie, Hämatologie und Stammzelltransplantation (Med. Klinik IV)
Prof. Dr. med. Tim H. Brümmendorf
tbruemmendorf@ukaachen.de
Berlin, 13353
Klinik für Innere Medizin mit Schwerpunkt Haematologie
Charité Berlin Campus Virchow Klinikum
Dr. Philipp Le Coutre
Bonn, 53127
Universitaetsklinikum Bonn
Medizinische Klinik 3
Onkologie, Hämatologie und Rheumatologie
Prof. Dr. Dominik Wolf
dominik.wolf@ukb.uni-bonn.de
Dresden, 01307
Universitätsklinikum Carl Gustav Carus
Medizinische Klinik und Poliklinik I
PD Dr. Rainer Ordemann
Essen, 45147
Universitätsklinikum Essen (AOER)
Klinik für Hämatologie
PD Dr. Jürgen Novotny
Freiburg, 79106
Universitätsklinikum Freiburg
Klinik für Innere Medizin I
Hamburg, 20246
Universitätsklinikum Hamburg-Eppendorf
Hämatologie
Dr. Gunhild von Arnsberg
Jena, 07747
Universitätsklinikum Jena
Hämatologie
Prof. Dr. Andreas Hochhaus
Leipzig, 04103
Universitätsklinikum Leipzig AOER
Selbstständige Abt. für Hämatologie
Prof. Dr. Dietger Niederwieser
Magdeburg, 39194
Hämatologie und Onkologie Schwerpunktpraxis
PD Dr. med. Kathleen Jentsch-Ullrich
Mannheim, 68169
Medizinische Fakultät der Universität Mannheim
Dr. Susanne Saußele
Hungary
Budapest, 1083
Semmelweis Egyetem I. Belgyógyászat
Prof. Judit Demeter
demjud6@gmail.com
demjud@bel1.sote.hu
Debrecen, 4032
Debreceni Egyetem Klinikai Központ, Belgyógyászati Inézet Hematológiai,
Tanszék
Prof. Dr. Árpád Illés
Gyor, 9023
Petz Aladár Megyei Oktató Kórház, II. dept. Internal Medicine-Haematology
Dr. Zoltán Gasztonyi
Kaposvár, 7400
Somogy Megyei Kaposi Mór Oktató Kórház
Hematológiai Osztály
Prof. Miklós Egyed
Szeged, 6723
Szegedi Tudományegyetem, Szent-Györgyi Albert Klinikai Központ, II. sz. Belgyógyászati Klinika és Kardiológiai Központ,
Hematológia
Professor Zita Borbényi
Szolnok, 5004
Jász-Nagykun-Szolnok Megyei Hetényi, Géza Kórház-Rendelőintézet
Dr. Gyorgy Ujj
Israel
Haifa, 35953
Hematology and Bone marrow transplant Rambam medical center
Dr. Noam Benyamini
Petah-Tikva, 49100
Rabin Medical Center; Hematology
Prof. Pia Raanani
Italy
Bergamo, 24127
A. O. Papa Giovanni XXIII
USC Ematologia
Prof. Alessandro Rambaldi
Bologna, 40138
Policlinico S. Orsola, Ematologia
Prof. Gianantonio Rosti
gianantonio.rosti@unibo.it, totorosti@gmail.com
Cagliari, 09121
Oncology Department - Hematology Unit and BMT Centre - Armando Businco Hospital Cagliari
Dr. Emanuele Angelucci
Catania, 95124
Ospedale Ferrarotto - AOU Policlinico - V. Emanuele
Dr. Fabio Stagno
Firenze, 50134
Azienda Ospedaliero Universitaria Careggi - Ematologia
Prof. Alberto Bosi
Genova, 16132
IRCCS AOU San Martino -IST
Prof. Angelo Michele Carella
Milano, 20132
Ospedale San Raffaele,
Unità Operativa di Ematologia e Trapianto Midollo Osseo
Dr. Fabio Ciceri
Monza, 20900
Azienda Ospedaliera S. Gerardo Di Monza
Unità di Ricerca Clinica, Sezione di Ematologia
Prof. Carlo Gambacorti – Passerini
carlo.gambacorti@unimib.it
Napoli, 80122
Università Federico II, Div. di Ematologia /
Dip. Di Medicina Clinica e Chirurgica
Prof. Fabrizio Pane
Pescara, 65124
P.O. dello Spirito Santo
Dipartimento di Ematologia U.O. Ematologia
Dr. Paolo Di Bartolomeo
Reggio Calabria, 89124
Haematology Department Azienda Ospedaliera Bianchi Melacrino Morelli
Dr. Bruno Martino
Roma, 00144
Ospedale S. Eugenio, U.O. di Ematologia
Associated Professor Elisabetta Abruzzese
Venezia-Mestre, 30174
U.O. di Ematologia
Ospedale dell'Angelo
Prof. Renato Bassan
ocme.ematologia@ulss12.ve.it
Mexico
Jalisco, 45170
Hospital General de Occidente
Departamento de Hematología
Dr. Carlos Roberto Best Aguilera
Mexico, D.F., 10700
Hospital Ángeles de Pedregal
Dr. Rafael Hurtado Monroy
Mexico, 11520
Hospital Español
Dr. José Luis Manuel Ayala Sánchez
Monterrey, NL, 6400
Monterrey International Research Center/
Hospital y Clinica Oca.
Dr. Enrique Baez de la Fuente
Netherlands
Amsterdam, 1081 HV
VU University Medical Center
Department of Hematology
Associated Professor Jeroen J.W.M. Janssen
jjwm.janssen@vumc.nl
Groningen, 9713 GZ
University Medical Center Groningen (UMCG)
Department of Hematology
Prof. Edo Vellenga
Norway
Bergen, 5020
Haukeland University Hospital
Depatment of Hematology
Prof. Dr. med. Bjørn Tore Gjertsen
Bjorn.Gjertsen@k2.uib.no
Trondheim, 7006
St. Olavs Hospital
Avd for blodyskdommer
Dr. Henrik Hjorth-Hansen
henrik.hjorth-hansen@ntnu.no
Poland
Chorzów, 41-500
SPZOZ Zespol Szpitali Miejskich, w Chorzowie Oddzial Hematologiczny
Dr. Sebstian Grosicki
Gdansk, 80-952
Uniwersyteckie Centrum Kliniczne
Klinika Hematologii i Transplantologii
Prof. Andrzej Hellmann
Katowice, 40-032
Szpital Kliniczny im. A Mielęckiego, ŚUM w Katowicach, Oddział Hematologii i
Transplantacji Szpiku
Prof. Slawomira Kyrcz-Krzemien
Kraków, 31-501
Dr. Tomasz Sacha
tomasz.sacha@uj.edu.pl
Lodz, 93-510
Wojewódzki Szpital Specjalistyczny im M. Kopernika
Klinika Hematologii Uniwersytetu Medycznego
Prof. Tadeusz Robak
Lublin, 20-081
Katedra i Klinika Hematologii i Transplantacji Szpiku SPSK 1w Lublinie
Dr. Marek Hus
Warszawa, 02-774
Instytut Hematologii i Transfuzjologii, Klinika Hematologii
Prof. Krzysztof Warzocha
Wroclaw, 50-367
Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu Katedra i Klinika Hematologii
Nowotworów Krwi i Transplantacji Szpiku
Prof. Kazimierz Kuliczkowski
Singapore
Singapore, 119228
Dept. of Haematology-Oncology
National University Hospital
Dr. Liang Piu Koh
Singapore, 169856
Singapore General Hospital
Dr. Charles Chuah
charles.chuah.t.h@sgh.com.sg
Singapore, 308433
Tan Tock Seng Hospital
Dr. Kiat Hoe Ong
Slovak Republic
Bratislava, 833 10
Narodny Onkologicky Ustav
Oddelenie Klinickej Hematologie
Dr. Ludmila Demitrovicova
Bratislava, 851 07
University Hospital Bratislava
Clinic of Hematology and Blood Transfusion
Associated Professor Martin Mistrik
(Contact person: Zuzana Sninska)
mistrik@pe.unb.sk
martinmistrik@yahoo.com
South Africa
Cape Town, 7925
UCT Private Academic Hospital
Division of Haematology
Nicolas Novitsky
Groenkloof, Gauteng, 0075
Mary Potter Oncology Centre
Dr. Graham L Cohen
Parktown, Gauteng, 2193
Wits Clinical Research
Prof. Paul Ruff
Pretoria, Gauteng, 0002
Department of Medical Oncology
Lydia Mary Dreosti
Saxonwold; Gauteng, 2196
Medical Oncology Centre Rosebank
Dr. Bernardo Leon Rapoport
South Korea
Anyang, 431-070
Hallym Sacred Heart Hospital
Internal Medicine
Prof. Dae-Young Zang
fhdzang@hallym.ac.kr
Busan, 602-715
Sung-Hyun Kim
Daegu, 700-712
Medicine Keimyung University
Dongsan Medical Center
Associated Professor Young-Rok Do
Jeonju, 561-712
Chonbuk National University Hospital
Division of Hematology
Professor Jae-Yong Kwak
Seoul, 110-746
Kangbuk Samsung Hospital
Internal Medicine
Associated Professor Suk-joong Oh
beatl51@gmail.com
Seoul, 137-701
The Catholic University of Korea
Division of Hematology, Department of Internal Medicine Seoul St. Mary's Hospital
Prof. Dong-Wook Kim
Spain
Badalona, 08916
Hospital ICO - Germans Trias i Pujol, Unidad de Investigación Clínica de Hematología
Dr. Cristina Motllo
Barcelona, 08035
Hospital Vall d'Hebron
Haematology Department
Dr. Pere Barba
Barcelona, 08036
Hospital Clinic de Barcelona
Hematology Department
Dr. Francisco Cervantes
Madrid, 28006
Hospital Universitario La Princesa, Hematology and Hemotherapy
Prof. Juan Luis Steegmann
Madrid, 28007
Hospital General Universitario Gregorio Marañón
Haematology Department
Dr. Santiago Osorio Prendes
Madrid, 28034
Hospital Universitario Ramon y Cajal
Oncology
Dr. Valentin Garcia Gutierrez
Madrid, 28040
Hospital Clinico Universitario San Carlos Haematology
Dr. Ascension Pena
Salamanca, 37007
Hospital Universitario de Salamanca, Haematology Department
Dr. Fermin Sanchez-Guijo
Santiago de Compostela, 15706
Hospital Clinico Universitario de Santiago De Compostela
Haematology
Dr. Manuel Mateo Perez Encinas
Toledo, 45004
Hospital Virgen De La Salud
Haematology Department
Dr. Luis Felipe Casado Montero
Valencia, 46010
Hospital Clinico Universitario de Valencia (CHUV)
Hematology and Medical Oncology
Prof. Juan Carlos Hernandez-Boluda
hernandez_jca@gva.es
Sweden
Linköping, 581 85
Linköping University Hospital
Dept. of Hematology
Dr. Dr. med. Kourosh Lotfi
kourosh.lotfi@lio.se
Lund, 22185
Skåne University Hospital
Dept of Hematology and Vascular Disorders
Prof. Johan Richter
Johan.Richter@med.lu.se
Örebro, 70185
University Hospital Örebro
Div. of Hematology
Mats Bjoereman
mats.bjoreman@orebroll.se
Stockholm, 17176
Karolinska University Hospital
Hematology
Associated Professor Leif Stenke
Umeå, 90185
Norrlands University Hospital
Hematological section
Dr. Berit Markevärn
Uppsala, 75185
Uppsala University Hospital
Department of Haematology
M.D. Ulla Olsson Stroemberg
Taiwan
Kaohsiung, 80756
Prof. Dr. Ta-Chih Liu
Tainan City, 710
M.D. Yin-Hsun Feng
Taipei, 10449
Mackay Memorial Hospital
Division of Hematology and Oncology, Department of Internal Medicine
Dr. Ken-Hong Lim
limkenhong@gmail.com
Taipei, 11217
Taipei Veterans General Hospital
Division of Hematology- Oncology
Dr. Jin-Hwang Liu
Taichung, 40447
China Medical University Hospital
Hematology and Oncology
Dr. Su-Peng Yeh
Taoyuan County, 33305
Professor Dr. Lee-Yung Shih
Thailand
Bangkok, 0000
Ratchathewi, Bangkok
Tontanai Numbenjapon
Bangkok, 10330
King Chulalongkorn Memorial Hospital
Division of Hematology
Department of Medicine
Udomsak U. Bunworasate
Bangkok, 10400
Ramathibodi Hospital
Division of Hematology
Department of Medicine
Ratchathewi
Dr. Pimjai Niparuck
Bangkok, 10700
Siriraj Hospital
Division of Hematology
Department of Medicine
Prof. Dr. Surapol S. Issaragrisil
Chiang Mai, 50200
Adisak A. Tantiworawi
Ukraine
Cherkasy, 18009
Municipal Institution "Cherkasy Regional Oncological Dispensary " of Cherkasy Regional Council
Regional Medical and Diagnostic Hematology Center
Dr. Halyna Pylypenko
Ivano-Frankivsk, 76008
Regional Clinical Hospital in Ivano-Frankivsk
Hematology Department
Associated Professor Nataliia Glushko
Khmel'nytsky, 29000
Khmelnytskyi Regional Hospital
Hematology Department
Dr. Grigoriy Rekhtman
grekhtman@yahoo.com
Kyiv, 03115
State Institution "National scientific center of clinical radiology NAMS of Ukraine"
Radiation oncohematology and stem cells transplantation department of hematology and transplantology division within Clinical Radiology
Prof. Dr. Iryna Dyagil
Kyiv, 04112
Kyiv City Clinical Hospital #9
Hematology Department #1
Dr. Svitlana Kalinina
kalinina.univ@gmail.com
Lviv, 79044
State Institution "Institute of Blood Pathology and Transfusion Medicine NAMS of Ukraine"
Hematology Department
Prof. Dr. Zvenyslava Maslyak
UK
Birmingham, B9 5SS
Birmingham Heartlands Hospital
Dr. Joanne Ewing
Cardiff, CF14 4XW
Haematology Department
University Hospital of Wales
Dr. Jonathan Kell
jonathan.kell@wales.nhs.uk
Leeds, LS9 7TF
St James Hospital
LCRF (Haematology)
Dr. Graeme Murray Smith
Stewart McConnell
Myeloid Research Nurse Stewart.mcconnell@nhs.net
Leicester, LE1 5WW
Leicester Royal Infirmary
HOPE Clinical Trials Unit
Dr. Ann Hunter
Liverpool, L7 8XP
Royal Liverpool University Hospital
Haematology Department
Professor Richard Clark
London, W12 0HS
Haematology Hammersmith Hospital
Catherine Lewis Centre
Dr. Dragana Milojkovic
Nottingham; NG5 1PB
Nottingham University Hospitals NHS Trust – City Campus
Dept. of Clinical Oncology
Dr. Jennifer Byrne
jenny.byrne@nottingham.ac.uk
Oxford, OX3 7 LE
Oxford Cancer and Haematology Centre
Churchill Hospital
Dr. Adam Mead
Sheffield, S10 2JF
Royal Hallamshire Hospital
Sameer Tulpule
USA
Alabama
Mobile, Alabama 36604
Clinical Trials Department
Thomas W Butler
Arkansas
Hot Springs, Arkansas 71913
Genesis Cancer Center
Dr. R. Timothy Webb
California
Anaheim, California 92801
Pacific Cancer Medical Center Inc.
Ajit S Maniam
Connecticut
Southington, Conneticut 06489
Cancer Center of Central Connecticut
Dr. Peter D. Byeff
Georgia
Atlanta, Georgia 30322
Winship Cancer Institute of Emory University
Hematology and Medical Oncology
Dr. Vamsi K. Kota
vamsi.kota@emory.edu
Hawaii
Honolulu, Hawaii 96819
Jennifer F. Carney
Illinois
Chicago, Illinois 60612
Hematology & Oncology John H. Stroger, Jr. Hospital of Cook County
Dr. Rosalind Catchatourian
(Contact Person: Dr. Augustin Haidau)
rcatchator@cookcountyhhs.org
Chicago, Illinois 60612
Rush University Medical Center
Dr. Jamile M. Shammo
Jamile_shammo@Rush.edu
KIMBERLY_KOETTER@rush.edu
Elena_Bogdanova@rush.edu
Chicago, Illinois 60612
M.D. Irum Khan
Maywood, Illinois 60153
Aileen Go
Indiana
Boise, Indiana 83706
Saint Alphonsus Health System
Dr. Kerry Pulver
heatwebb@sarmc.org
Indianapolis, 46237
Indiana Blood & Marrow Transplantation
Dr. Luke Akard
Louisiana
Lafayette, Louisiana 70503
Dr. Salman Malad
Shreveport, Louisiana 71103
Feist-Weiller Cancer Center
LSU Health Sciences Center
Dr. Reinhold Munker
rmunker@lsuhsc.edu
Maryland
Bethesda, Maryland 20817
Center for Cancer and Blood Disorders
Dr. Ralph Boccia
rboccia@ccbdmd.com
Massachusetts
Worcester, Massachusetts 01655
UMass Memorial Medical Center
Dr. Jan Cerny
Michigan
Ann Arbor, Michigan 48106
St. Joseph's Mercy Hospital
Dr. Christopher Reynolds
Christopher_reynolds@ihacares.com
Ann Arbor, Michigan 48109
University of Michigan
M.D. Moshe Talpaz
mtalpaz@umich.edu
Grosse Pointe Woods, Michigan 48236
St. John Health
Van Elslander Cancer Center
Dr. Carrie L. Dul
Minnesota
Saint Louis Park, Minnesota 55416
Metro MN CCOP
Dr. Daniel Anderson
Mississippi
Tupelo, Mississippi 38801
North Mississippi Hematology and Oncology Assoc., Ltd.
Dr. Andrew Kellum
Missouri
Kansas City, Missouri 64131
Dr. Kelly B Pendergrass
Nebraska
Omaha, Nebraska 68114
Dr. Stefano Tarantolo
New Jersey
Hackensack, New Jersey 07601
Hackensack University Medical Center
John Theurer Cancer Center
Dr. Stefan Faderl
sfaderl@hackensackumc.org
New Mexico
Farmington, New Mexico 87401
San Juan Oncology Associates
Dr. Jeffrey Neidhart
New York
Mineola, New York 11501
Winthrop University Hospital
Michael E. Garrison
New York, New York 10003
Mount Sinai Beth Israel Medical Center
Phillips Ambulatory Care Center
Dr. Ilan Shapira
New York, New York 10021
Memorial Sloan-Kettering Cancer
Dr. Michael J. Mauro
Rochester, New York 14642
University of Rochester Medical Center
James P. Wilmot Cancer Center
Jason H. Mendler
Syracuse, New York 13210
Upstate Medical University
Bernard J. Poiesz
North Carolina
Durham, North Carolina 27710
Dr. David A Rizzieri
Pinehurst, North Carolina 28374
FirstHealth Out Patient Cancer Center
Charles Kuzma
Ohio
Cleveland, Ohio 44106
University Hospitals
Brenda W. Cooper
Cincinnati, Ohio 45267
Stephen Medlin
Pennsylvania
Gettysburg, Pennsylvania 17325
Gettysburg Cancer Center
Dr. Satish Shah
drshah@gettysburgoncology.com
South Carolina
Charleston, South Carolina 29425
Hollings Cancer Center Medical University of South Carolina
Dr. Alice Mims
Greenville, South Carolina 29615
Greenville Health System
M.D. Saeeda Chowdhury
Tennessee
Associates In Oncology and Hematology
Chattanooga, Tennessee 37421
Dr. Jitendra Gandhi
Texas
Houston, Texas 77030
MD Anderson Cancer Center
M.D. Jorge Cortes
(Contact person: Maria "Cookie" Gavino)
jcortes@mdanderson.org
Utah
Salt Lake City, Utah 84106
IHO Corp/ Utah Cancer Specialists
Dr. Stephen Kendall
Salt Lake City, Utah 84112
The University of Utah
Huntsman Cancer Institute
Michael W. Deininger
Washington
Seattle, Washington 98101
David Aboulafia
Seattle, Washington 98109
Dr. Vivian Oehler
Wisconsin
Green Bay, Wisconsin 54303
Green Bay Oncology
Dr. Anthony Jaslowski
Milwaukee, Wisconsin 53226
Ehab Atallah
EUROSKI (EUROStopKinaseInhibitor)
Study title
EUROSKI (EUROStopKinaseInhibitor) = Stopping TKI in patients with CML in complete molecular remission (MR4)
Scientific title
Multicenter prospective trial estimating the persistence of molecular remission in chronic myeloid leukemia after stopping TKI (EUDRACT 2011-000440-22, ClinicalTrials.gov NCT01596114)
Indication and most important inclusion criteria
Chronic myeloid leukemia (CML) in CP on treatment with any TKI in first line or in second line because of toxicity to first line TKI or with TKI in combination
Potential participants of the study should have been treated with TKIs for at least 3 years and should have been in MR4 (less than 0,01% BCR-ABL IS) for at least one year.
At least complete molecular remission MR4 (either (i) detectable disease <=0.01% BCR-ABL IS or (ii) undetectable disease in cDNA with >=10,000 ABL or >=24,000 GUS transcripts) for at least one year; at least three PCR-results with MR4 within the last year (±2 months) before study entry and no PCR-results >0.01% during the same period.
Before inclusion confirmation of MR4 through a EUTOS-CMR laboratory.
Baseline data and documentation on treatment before study entry available.
Known baseline data at diagnosis, EURO-Score
Patients with previous or planned allogeneic stem cell transplantation will be excluded.
Short description of intervention
Stopping TKI in patients with CML in complete molecular remission (MR4)
Type of study
Treatment discontinuation trial
Current status
Recruitment completed
Study sponsor
Scientific lead / contact
Saussele, Dr. med. Susanne
Universitätsklinikum Mannheim, Germany
Principal investigator
Mahon, Prof. Dr. François-Xavier
CHU de Bordeaux, France
Additional information
Short protocol in European LeukemiaNet
Study description in US register ClinicalTrials.gov, a service of the U.S. National Institutes of Health
Study centers / principal investigators
Czech Republic
Brno
Masaryk University and University Hospital Brno
Dpt. of Internal Medicine, Hematology and Oncology
Prof. Jiri Mayer
Hradec Králové,
University Hospital Hradec Králové
(Fakultni nemocnice HradeKrélové)
4th Department of Internal Medicine - Hematology
Dr. Jaroslava Voglová
Prague
Institute of Hematology and Blood Transfusion, (Ustav hematologie a krevni transfuze)
Prof. Hana Klamova
The Royal Vinohrady Teaching Hospital (Fakultni nemocnice Kralovske Vinohrady)
Dpt. of Internal Medicine and Hematology
Dr. Olga Cerna
Plzen
University Hospital Plzen
Dpt. of Hematology and Oncology
Dr. Michal Karas
Olomouc
University Hospital Olomouc
Dpt. of Hematology and Oncology
Dr. Edgar Faber
Finland
Helsinki
Helsinki University Central Hospital Division of Haematology
Department of Medicine
Prof. Kimmo Porkka
France
Angers
CHU d'Angers
Service des Maladies du Sang
Dr. Martine Gardembas-Pain
Bordeaux
Centre Hospitalier Universitaire (CHU) de Bordeaux
Hôpital Haut Lévèque
Pessac
Prof. François-Xavier Mahon
Bordeaux Bergonie
Institut Bergonié
Dr. Gabriel Etienne
Clermont Ferrand
CHU ESTAING
Prof. Marc Berger
Le Chesnay
Hôpital André Mignot,
Service d'Hématologie et d'Oncologie
Prof. Philippe Rousselot
Lille
Universitaire Regional (CHRU) de Lille
Centre Hospitalier
Hôpital Claude Huriez
Dr. Valérie Coiteux
Lyon
Centre Hospitalier Universitaire des Hospices Civils de Lyon (CHU des HCL)
Hôpital Edouard Herriot
Dr. Franck Nicolini
Marseilles
Centre de Lutte Contre le Cancer (CLCC) de Marseille
Institut Paoli-Calmettes (IPC)
Dr. Aude Charbonnier
Nantes
Centre Hospitalier Universitaire (CHU) de Nantes
Hôpital Hôtel-Dieu,
Prof. Viviane Dubruille
Nice
Centre Hospitalier Universitaire (CHU) de Nice
Hôpital de l'Archet
Dr. Laurence Legros
Paris 10
Hôpital Saint-Louis
Dr. Delphine Rea
Paris 15
Hôpital Necker-Enfants Malades
Service Hématologie
Prof. Bruno Varet
Poitiers
Centre Hospitalier Universitaire (CHU) de Poitiers
Hopital de la Milétrie
Prof. François Guilhot
Rennes
Hôpital Pontchaillou
Dr. Martine Escoffre.Barbe
Toulouse
Centre Hospitalier Universitaire (CHU) de Toulouse
Hôpital Purpan
Dr. FrançoiseRigal-Huguet
Tours
CHU de Tours
Dr. Emmanuel Gyan
Vandoeuvre les Nancy
Centre Hospitalier Universitaire (CHU) de Nancy
Hôpital de Brabois
Dr. Agnès-Paule Guerci
Germany
Aachen
Universitätsklinikum der RWTH Aachen
Medizinische Klinik IV
Prof. Dr. med. Tim Henrik Brümmendor
Bayreuth
Klinikum Bayreuth GmbH
Medizinische Klinik IV
PD Dr. med. Alexander Kiani
Bonn
Rheinische Friedrich-Wilhelms-Universität Bonn
Medizinische Klinik III
Dr. med. Viktor Janzen
Chemnitz
Klinikum Chemnitz gGmbH
Klinik für Innere Medizin III
Dr. med. Regina Herbst
Dresden
Gemeinschaftspraxis für Hämatologie und Onkologie
PD Dr. med. T. Illmer
Freiburg
Universitätsklinikum Freiburg
Abt. Innere Medizin I
Dr. med. Cornelius Waller
Hamburg
Universitätsklinikum Hamburg-Eppendorf
Heilbronn
Schwerpunktpraxis Onkologie
Dr. med. Jolanta Dengler
Jena
Universitätsklinikum Jena
Klinik und Poliklinik für Innere Medizin II
Hämatologie/Onkologie/Stammzelltransplantation
Prof. Dr. med. Andreas Hochhaus
Kempten
Klinikum Kempten-Oberallgäu gGmbH
Hämatologie, Onkologie und Palliativmedizin
Dr. med. Stefan Hanzel
Leer
Onkologische Schwerpunktpraxis
Dr. med. Carsten Janssen
Mannheim
Universitätsklinikum Mannheim
III. Medizinische Klinik
PD Dr. med. Susanne Saussele
Marburg
Klinikum der Philipps-Universität Marburg
Klinik für Hämatologie/Onkologie/Immunologie
Prof. Dr. med. Andreas Burchert
Munich
Klinikum rechts der Isar der
Technischen Unversität München
Oldenburg
Klinikum Oldenburg
Klinik für Onkologie und Hämatologie
Prof. Dr. med. Doris Kraemer
Straubing
MVZ Klinikum Straubing GmbH
Dr. med. Gernot Freunek
Wendlingen
Onkologische Schwerpunktpraxis
Dr. med. Robert Eckert
Würzburg
Universitätsklinikum Würzburg
Hämatologie/ Onkologie
Dr. Goebeler
Greece
Athens
Laikon General Hospital
Propaedeutic University of Athens - School of Medicine
Prof. Panayiotis Panayiotidis
Netherlands, The
Amsterdam
VU medisch centrum, secr. Hematologie
Prof. Gert Ossenkoppele
Norway
Oslo
Mr. Tobias Gedde-Dahl
Stavanger
Stavanger University Hospital
Department of Hematology and Oncology,
Dr. Majeed Waleed
Tromsø
University Hospital of Northern Norway
Department of Hematology
Prof. Franz Gruber
Trondheim
Department of Cancer, Research and Molecular Medicine
Prof. Henrik Hjorth-Hansen
Portugal
Lisbon
Instituto Portugues de Oncologia Francisco Gentil de Lisboa
Hematology
Dr. Antonio Almeida
Sweden
Linköping
Univ hospital Linköping
Haematology Centre
Dr. Kourosh Lotfi
Luleå
Sunderby hospital
Dept of Medicine
Dr. Kristina Myhr-Eriksson
Lund
Skåne University hospital
Haematology Centre
Prof. Johan Richter
Örebro
Univ hospital Örebro
Haematology Centre
Dr. Mats Björeman
Stockholm, Huddinge
Karolinska Univ hospital Huddinge
Haematology Centre
Dr. Sören Lehmann
Stockholm, Karolinska
Karoliniska Univ sjh Solna
Haematology Centre
Dr. Leif Stenke
Sundsvall
Länssj Sundsvall
Dept of Medicine
Dr. Anders Själander
Umeå
Haematology Centre
Norrlands Univ hospital
Dr. Berit Markevärn
Uppsala
Uppsala University hospital
Hematology section
Dr. Ulla Olsson-Strömberg
TIGER (CML V) = Nilotinib or nilotinib + peginterferon with the aim to discontinue treatment
Study title
TIGER (CML V) = Nilotinib or nilotinib + peginterferon with the aim to discontinue treatment [Europe]
Scientific title
TIGER = Treatment optimization of newly diagnosed Ph/BCR-ABL positive patients with chronic myeloid leukemia (CML) in chronic phase with nilotinib vs. nilotinib plus interferon alpha induction and nilotinib or interferon alpha maintenance therapy (EudraCT 2010-024262-22 clinicaltrials.gov NCT01657604).
Indication and most important inclusion criteria
Patients with newly diagnosed chronic phase CML and cytogenetic confirmation of Philadelphia chromosome [t(9;22)(q34;q11)]. Patients should be newly treated or non-treated (hydroxyurea for 6 months and imatinib or nilotinib for a duration of up to 6 weeks are permitted).
Short description of intervention
Attempt of CML treatment optimization. There will be two groups in this study: one group will receive nilotinib alone, the other group will receive a combination of nilotinib and interferon alpha. During a later treatment phase, nilotinib or interferon alpha will be given as maintenance therapy, and discontinued if MR improves further for at least 12 months.
Type of study
First-line trial
Current status
No longer recruiting
Study sponsor
Friedrich-Schiller-Universität Jena
Germany
Scientific lead / contact
Hochhaus, Prof. Dr. med. Andreas
Universitätsklinikum Jena
Principal investigator
Prof. Dr. med. Andreas Hochhaus
Universitätsklinikum Jena
Abteilung Hämatologie und Internistische Onkologie
Additional information
- Study description in the EU Clinical Trials Register which is hosted by the European Medicines Agency (EMA)
- Study description in the US register ClinicalTrials.gov, a service of the U. S. National Institutes of Health
- Short protocol in Kompetenznetz Leukämien
- German patient information sheet
Study centers
Czech Republic
Brno
University Hospital and Masaryk University Brno
Daniela Zackova, MD
Germany
Aachen
Universitätsklinikum Aachen
Medizinische Klinik IV
Steffen Koschmieder, Prof. MD
Amberg
Gesundheitszentrum St. Marien GmbH
Onkologie/ Hämatologie Onkologisches Zentrum
Ludwig Fischer von Weikersthal, MD
Arnsberg
MVZ am Klinikum Arnsberg GmbH
Hämatologie - Internistische Onkologie
Karsten Schulmann, MD
Aschaffenburg
Studienzentrum Drs. Klausmann/Dr. Welslaus
Martine Klausmann, MD
Bad Saarow
Helios Klinikum Bad Saarow
Klinik für Hämatologie, Onkologie und Palliativmedizin
Peter Reichardt, PD MD
Bayreuth
Klinikum Bayreuth GmbH
Alexander Kiani, PD MD
Berlin
Charité - Campus Benjamin Franklin
Medizinische Klinik III
Igor Wolfgang Blau, PD MD
Berlin
Charité CVK, CC14,
Klinik für Hämatologie und Onkologie
Philipp le Coutre, MD
Berlin
Vivantes Netzwerk für Gesundheit GmbH
Klinikum Neukölln
Klinik für Innere Medizin - Hämatologie und Onkologie
Maike de Wit, Prof. MD
Bonn
Universitätsklinikum Bonn
Med. Klinik und Poliklinik III, Hämatologie
Viktor Janzen, MD
Bonn
Evangelische Kliniken Bonn gGmbH
Johanniterkrankenhaus
Yon Dschun Ko, Prof. MD
Braunschweig
Städtisches Klinikum Braunschweig gGmbh
Medizinische Klinik III – Hämatologie
Ulrike Helbig, MD
Bremen
DIAKO Ev. Diakonie-Krankenhaus gGmbH
Medizinische Klinik II
Johannes Kullmer, MD
Bremen
Klinikum Bremen-Mitte gGmbH
Bernd Hertenstein, Prof. MD
Chemnitz
Klinikum Chemnitz gGmbH
Klinik für Innere Medizin III, PD MD
Coburg
Praxis Dr. med. Zöller
Thomas Zöller, MD
Cottbus
Onkologische Schwerpunktpraxis
Ulrich von Grünhagen, MD
Dresden
Onkologische Schwerpunktpraxis
Thomas Illmer, PD MD
Dresden
Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden
Rainer Ordemann, PD MD
Dresden
Gemeinschaftspraxis Mohm / Prange-Krex
Johannes Mohm, MD
Düsseldorf
Marien Hospital Düsseldorf
Klinik für Onkologie, Hämatologie und Palliativmedizin
Aristoteles Giagounidis, PD MD
Eisenach
Onkologisch-Hämatologische Schwerpunktpraxis
Klaus Blumenstengel, MD
Erlangen
Universitätsklinikum Erlangen
Medizinische Klinik 5 - Hämatologie und int. Onkologie
Babette Häcker, MD
Erlangen
Onkologische Schwerpunktpraxis Erlangen
Onkologie, Hämatologie
Stefan Krause, Prof. MD
Eschweiler
St.-Antonius-Hospital
Klinik für Hämatologie Onkologie
Frank Schlegel, MD
Essen
Universitätsklinikum Essen
Klinik für Hämatologie
Jürgen Novotny, PD MD
Freiburg
Universitätsklinikum Freiburg
Abteilung Innere Medizin I - Hämatologie und Onkologie
Cornelius Waller, Prof. MD
Fulda
MVZ-Osthessen GmbH
Klinikum Fulda Tumorklinik
Heinz-Gert Höffkes, Prof. MD
Gerlingen
Praxis Dr. med. Schmitt
Hans R. Schmitt, PD MD
Goch
Wilhelm-Anton-Hospital gGmbH
Klinik für Innere Medizin, Hämatologie und Internistische Onkologie
Volker Runde, Prof. MD
Goslar
Dr. med. Hans Werner Tessen
Facharzt für Innere Medizin
Hans Werner Tessen, MD
Göttingen
Georg-August Universität Göttingen
Abteilung Hämatologie und Onkologie
Florian Zettl, MD
Greifswald
Universitätsmedizin Greifswald
Klinik und Poliklinik für Innere
Christian-Andreas Schmidt, Prof. MD
Güstrow
Internistische Gemeinschaftspraxis
Stefan Wilhelm, MD
Hagen
Katholisches Krankenhaus Hagen gem. GmbH
Klinik für Hämatologie und Onkologie
Hans-Walter Lindemann. MD
Halle
Hämatologisch-onkologische Gemeinschaftspraxis
Claudia Spohn, MD
Hamburg
Asklepios Klinik St. Georg, Abteilung Hämatologie, Onkologie, Stammzelltransplantation
Norbert Schmitz, Prof. MD
Hamburg
Hämatologisch-Onkologische Praxis Altona
Struensee-Haus
Erik Engel, MD
Hamburg
MVZ Hämatologie-Onkologie
Svenja Neumann, MD
Hamburg
Universitätsklinikum Hamburg- Eppendorf
Medizinische Klinik 2
Philippe Schafhausen, MD
Hamm
St. Marien-Hospital Hamm
Klinik für Hämatologie und Onkologie
Heinz Dürk, MD
Hamm
Evangelisches Krankenhaus Hamm
Elisabeth Lange, MD
Hannover
Medizinische Hochschule Hannover
Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation
Matthias Eder, Prof. MD
Hannover
Mediprojekt
Gesellschaft für Medizinstatistik und Projektentwicklung
Michael P. Koenigsmann, Prof. MD
Heidelberg
Universitätsklinikum Heidelberg
Innere Medizin V: Hämatologie, Onkologie und Rheumatologie
Eike C. Buss, MD
Heilbronn
Internistische Gemeinschaftspraxis Heilbronn
Jolanta Dengler, MD
Hildesheim
St. Bernward Krankenhaus Hildesheim
Ulrich Kaiser, Prof. MD
Homburg/Saar
Universitätsklinikum des Saarlandes Klinik für Innere Medizin I
Michael Pfreundschuh, Prof. MD
Idar-Oberstein
Klinikum Idar-Oberstein GmbH
Innere Medizin I (Hämatologie/Onkologie)
Eva Roemer, MD
Ingolstadt
MVZ Onkologie Ingolstadt
Ole Maywald, MD
Jena
Universitätsklinikum Jena
Klinik für Innere Medizin II
Abt. Hämatologie und internistische Onkologie
Andreas Hochhaus, Prof. MD
Jena
Eps- early phase solutions GmbH
Klaus Ruffert, PD MD
Kaiserslautern
Westpfalz-Klinikum GmbH
Innere 1
Stefan Mahlmann, MD
Karlsruhe
St. Vincentius-Kliniken Karlsruhe
Michael Schatz, MD
Karlsruhe
Städtisches Klinikum Karlsruhe gGmbH
Medizinische Klinik III: Hämatologie/Onkologie
Martin Bentz, Prof. MD
Kiel
Universitätsklinikum Schleswig-Holstein
II. Medizinische Klinik und Poliklinik im Städtischen Krankenhaus Kiel
Björn-Niklas Heydrich, MD
Koblenz
InVO, Institut für Versorgungsforschung in der Onkologie
Jörg Thomalla, MD
Krefeld
Onkologische Gemeinschaftspraxis Dr. M. Neise u. Dr. A. Lollert
Michael Neise, MD
Kronach
Onkologische Schwerpunktpraxis
Martina Stauch, MD
Kronach
Onkologische Schwerpunktpraxis
Peter Anhut, MD
Landshut
Hämatologisch-Onkologische Tagesklinik'
Ursula Vehling-Kaiser, MD
Lebach
Onkologisches Zentrum Gemeinschaftspraxis für Hämato-/ Onkologie
Abt. für Hämato-/ Onkologie im Caritas Krankenhaus
Stephan Kremers, MD
Leer
Onkologisches Schwerpunktpraxis
Lothar Müller, MD
Leipzig
Universitätsklinikum Leipzig
Department für Innere Medizin
Dietger Niederwieser, Prof. MD
Leipzig
Dr. Aldaoud - Dr. Schwarzer Forschungsgesellschaft mbH
Andreas Schwarzer, MD
Limburg/Lahn
Krankenhausgesellschaft St. Vincenz mbH Limburg
Thomas Neuhaus, PD MD
Magdeburg
Gemeinschaftspraxis Uhle, Müller, Kröning, Jentsch-Ullrich
Kathleen Jentsch-Ullrich, PD MD
Mainz
Universitätsmedizin der Johannes- Gutenberg Universität
III. Medizinische Klinik und Poliklinik, Hämatologie, internistische Onkologie und Pneumologie
Thomas Kindler, MD
Mainz
Internistische Gemeinschaftspraxis Onkologie/Hämatologie
Ute Kreiter, MD
Mannheim
Mannheimer Onkologie Praxis
Christoph Plöger, MD
Mannheim
Universitätsmedizin Mannheim
III. Medizinische Klinik
Susanne Saußele, MD
Marburg
Klinikum der Philipps-Universität Marburg
Klinik für Innere Medizin
Schwerpunkt Hämatologie, Onkologie und Immunologie
Andreas Burchert, Prof. MD
Minden
Johannes Wesling Klinikum Minden
Mühlenkreikliniken (AöR)
Hämatologie/Onkologie
Hans J. Tischler, MD
Mutlangen
Stauferklinikum Schwäbisch Gmünd, Zentrum Innere Medizin
Holger F. Hebart, Prof. MD
München
Gemeinschaftspraxis Hämatologie/ Onkologie
Burkhard Schmidt, MD
München
Klinikum rechts der Isar
III. Medizinische Klinik und Poliklinik
Philip Jost, MD
München
MHP Münchener Hämatologie Praxis
Torsten Haferlach, Prof. MD
München
Hämatologisch-Onkologische Schwerpunktpraxis
Helmut Hitz, MD
München
Tumorzentrum München Süd
Klinikum Harlaching
Thomas Will, MD
München
Hämatologisch-Onkologische Gemeinschaftspraxis
Oliver Stoetzer, MD
München
Universitätsklinikum Grosshadern
LMU München
Werner Olipitz, MD
Neumarkt
Onkologische und hämatologische Schwerpunktpraxis
Ekkehart Ladda, MD
Nürnberg
Ambulantes BehandlungsCentrum des Klinikums Nürnberg
Hämatologie/Onkologie, Nuklearmedizin
Christiane Falge, MD
Oldenburg
Klinikum Oldenburg
Klinik für Onkologie und Hämatologie / Innere Medizin II
Doris Kraemer, Prof. MD
Paderborn
Brüderkrankenhaus St. Josef Paderborn
Tobias Gaska, Prof. MD
Passau
Klinikum Passau
II. Medizinische Klinik
Thomas Südhoff, Prof. MD
Recklinghausen
Klinikum Vest
Behandlungszentrum Recklinghausen
Medizinische Klinik III
Otto Kloke, Prof. MD
Regensburg
Universitätsklinikum Regensburg
Abteilung für Hämatologie und internistische Onkologie
Matthias-Georg Edinger, Prof. MD
Regensburg
Krankenhaus Barmherzige Brüder Regensburg
Klinik für Onkologie und Hämatologie
Michael Schenk, MD
Reutlingen
Kreiskliniken Reutlingen GmbH
Klinikum am Steinenberg
Medizinische Klinik I
Alexander Wacker, MD
Rostock
Universitätsmedizin Rostock
ZIM II Klinik für Hämatologie und Onkologie
Christian Junghanß, Prof. MD
Schweinfurt
Leopoldina-Krankenhaus
Hans Reinel, MD
Schwäbisch Hall
Diakonie-Klinikum Schwäbisch Hall gGmbH
Innere Medizin III: Sektion für Onkologie und Hämatologie
Daniel Debatin, MD
Sindelfingen
Klinikverbund Südwest
Kliniken Sindelfingen-Böblingen gGmbH
Markus Ritter, PD MD
Stuttgart
Diakonie Klinikum Stuttgart
Medizinische Klinik
Else Heidemann, Prof. MD
Trier
Klinikum Mutterhaus der Borromäerinnen
Rolf Mahlberg, MD
Trier
Internistische Gemeinschaftspraxis
Bernhard Rendenbach, MD
Tübingen
Medizinische Universitätsklinik
Department für Innere Medizin
GCP Studienzentrale der Abteilung 2
Robert Möhle, Prof. MD
Ulm
Universitätsklinikum Ulm
Klinik für Innere Medizin III
Frank Stegelmann, MD
Villingen-Schwenningen
Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH
Wolfram Brugger, Prof. MD
Waiblingen
Rems-Murr-Klinik Waiblingen
Stefani Parmentier, MD
Weiden
Medizinisches Versorgungszentrum GmbH
Robert Funck
Wendlingen
Dres. med. T. Kamp - R. Eckert
Innere/Hämatologie/Onkologie
Torsten Kamp, MD
Würselen
Onkologische Gemeinschaftspraxis Würselen und Stolberg
Christoph Maintz, MD
Würzburg
Universitätsklinikum Würzburg
Medizinische Klinik und Poliklinik II
Volker Kunzmann, PD MD
Switzerland
Aarau
Kantonspital Aarau AG
Nathan Cantoni, MD
Bern
Inselspital Bern
Gabriela Baerlocher, Prof. MD
Basle
Universitätsspital Basel
Dominik Heim, MD
Geneva
Hopitaux Universitaires de Genève
Yves Chalandon, Prof. MD
Lausanne
Hopitaux Universitaires de Genève
Olivier Spertini, Prof. MD
Liestal
Kantonsspital Baselland
Genviève Favre, MD
Luzern
Luzerner Kantonsspital
Michael Gregor, MD