CALLS = CML and ALL Low Level Mutation Study in the UK [UK]

Study title

CALLS Study = CML and ALL Low Level Mutation Study

Scientific title

A Cohort Study To Establish the Prevalence of Mutations in Patients with CML Who Meet the ELN Criteria for Warning or Failure and Patients With Ph+ALL With Detectable BCR-ABL1 Currently Being Treated With First or Subsequent TKI Therapy in the UK Using Next Generation Sequencing. ( no NCT03647215)

Type of study

Other trials

Current status

No longer recruiting

What is the purpose of the study

This is an observational study to establish the prevalence of mutations in patients with CML who meet the ELN criteria for warning or failure and patients with Ph+ ALL with detectable BCR-ABL currently being treated with first or subsequent TKI therapy in the UK.

Key inclusion criteria

Adult patients (age ≥ 18 years) with CML (in all phases of disease) or Ph+ ALL with detectable BCR-ABL levels who are being treated with a first or subsequent tyrosin kinase inhibitor (TKI).

Patients with CML must meet the warning or failure criteria as per the ELN guidelines for first second and subsequent treatment line, including:

BCR-ABL/ABL IS transcripts > 10% at 3 months
BCR-ABL/ABL IS transcripts > 1% at 6 months
BCR-ABL/ABL IS transcripts > 0.1% at 12 months or later OR
Ph+ve ALL patients with any level of BCR-ABL/ABL IS transcripts who are not eligible for UKALL 14 or are not currently enrolled in UKALL 14

Key exclusion criteria

Where can I find additional information

Study sponsor

Incyte Biosciences UK

Scientific lead / contact

Study Director: Michael Thompson, MD Incyte Biosciences UK

Principal investigator

Hugues de Lavallade

Study centers / principal investigators


University Hospital Waterford
Waterford, X91 ER8E


Royal Cornwall Hospital
Truro, Cornwall, TR1 3LQ

Royal Devon & Exeter Hospital
Exeter, Devon, EX2 5DW

Broomfield Hospital Chelmsford
Chelmsford, Essex, CM1 7ET

Derriford Hospital
Plymouth, Devon, PL6 8DH

Queen’s Hospital
Romford, Essex, RM7 0AG

Aberdeen Royal Infirmary
Aberdeen, Foresterhill, AB25 2ZN

Queen Alexandra Hospital
Portsmouth, Hampshire, PO6 3LY

Medway Maritime Hospital
Gillingham, Kent, ME75NY

Blackpool Victoria Hospital
Blackpool, Lancashire, FY3 8NR

Royal Oldham Hospital
Manchester, Lancashire, OL1 2JH

Queens Medical Centre
Nottingham, Nottinghamshire, NG7 2UH

Ipswich Hospital
Ipswich, Suffolk, IP4 5PD

Heart of England NHS Foundation Trust
Birmingham, West Midlands, B9 5SS

Russells Hall Hospital
Dudley, West Midlands, DY1 2HQ

King’s College Hospital
London, SE5 9R

Bradford Royal Infirmary
Bradford, West Yorkshire, BD9 6RJ

St James’s University Hospital
Leeds, West Yorkshire, LS9 7TF

Monklands Hospital
Airdrie, ML6 0JS

Bristol Haematology and Oncology Centre
Bristol, BS2 8ED

Addenbrooke’s Hospital
Cambridge, CB2 0QQ

University Hospital Wales
Cardiff, CF14 4XW

Croydon University Hospital, Croydon Health Services NHS Trust
Croydon, CR7 7YE

Western General Hospital
Edinburgh, EH4 2XU

Beatson West of Scotland Cancer Centre
Glasgow, G12 0YN

Guy’s Hospital
London, SE1 9RT

King’s College Hospital
London, SE5 9RS

The James Cook University Hospital, South Tees Hospitals NHS Foundation Trust
Middlesbrough, TS4 3BW

Oxford University Hospitals NHS Foundation Trust
Oxford, OX4 2PG

Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS FT
Sheffield, S10 2JF

Royal Stoke University Hospital, Cancer Centre, University Hospitals of North Midlands NHS Trust
Stoke-on-Trent, ST4 6QG

Singleton Hospital
Swansea, SA2 8QA