KISS = Kinase Inhibition With Sprycel Start up [New Zealand]

Study title

KISS: Kinase Inhibition With Sprycel Start up

Scientific title

KISS Study: A Phase II Study of Dasatinib Followed by Imatinib in Newly Diagnosed, Previously Untreated Patients With Chronic Phase CML ( NCT03193281)

Type of study

Trials that are no longer recruiting



Current status

No longer recruiting

Other trial ID


What is the purpose of the study

This study will assess the efficacy and safety of a treatment plan for patients with newly diagnosed CML-CP. In the first study stage, patients will be given dasatinib (Sprycel) to more rapidly induce a molecular response (MR3.0). At 13 months, patients will be switched to imatinib to maintain CML in that remission.
Patients who do not achieve confirmed MR3.0 at 13 months will not be eligible to switch to imatinib treatment and will continue on dasatinib treatment.

Key inclusion criteria

This study includes male or female patients who:

– are at least 18 years old
– have an Eastern Co-Operative Oncology Group (ECOG) status of 0, 1 or 2
– have been diagnosed with chronic myeloid leukemia in chronic phase within 3 months of enrolment
– have cytogenetic or molecular confirmation of Philadelphia chromosome (Ph+) or variants of (9;22) translocations

Key exclusion criteria

Estimated primary completion date

December 2025

Where can I find additional information

Study description in the US register, a service of the U. S. National Institutes of Health

Study sponsor

University of Auckland, New Zealand, in collaboration with Leukaemia & Blood Cancer, New Zealand

Scientific lead / contact

Professor Peter Browett, University of Auckland, New Zealand

Principal investigator

Professor Peter Browett, University of Auckland, New Zealand

Study centers / principal investigators

New Zealand

Auckland City Hospital
Principal Investigator: Prof Peter Browett

Middlemore Hospital
Principal Investigator: Dr Gordon Royle

Christchurch Hospital
Principal Investigator: Dr Emma Jane McDonald

Dunedin Hospital
Principal Investigator: Dr Lucy Pemberton

Waikato Hospital
Principal Investigator: Humphrey Pullon

Taranaki Base Hospital
New Plymouth
Principal Investigator: Bart Baker

Palmerston North Hospital
Palmerston North
Principal Investigator: Bart Baker

North Shore Hospital
Principal Investigator: Henry Chan

Wellington Hospital
Principal Investigator: Victoria Campion