The Patient Preference Study

We are pleased to say that we have concluded data collection for our Preference Study. As a reminder, we were running a Patient Preference Study (PPS) to be able to assess the relative importance of treatment attributes in the decision-making of adult patients with Chronic Phase CML. This was a short, 20-30minute online DCE (Discrete Choice Experiment) survey. DCEs are a preference methodology in which participants are asked to make choices between a series of hypothetical alternatives described in terms of a set of attributes, with each attribute assigned a specific level. In our case, patients were presented with 12 choice tasks where they were asked to imagine that they were starting their current line of therapy and to choose between two hypothetical treatments. We wanted to see how patients make decisions based on the different level of side effects they were presented with and determine which treatment attributes were more important to them (such as fasting requirements, response and adverse event profile).

This was an important, multi country study where we were looking to recruit 900 patients in the USA, Canada, Italy, France, Germany, Spain, UK, China and Japan for survey completion. Our interim analysis and publication is currently pending so stay tuned for this!

In the meantime, we are very pleased to announce that we have submitted preliminary data to both SOHO and ESH and both abstracts have been accepted. The SOHO report based our analysis on data received from the USA and Canada whilst ESH included data received from the UK and Spain. The conclusions drawn from the data are slightly different given the sample size and the countries analysed, however when we looked at the 82 responses in the ESH data, the most important side effect for patients during treatment were fatigue followed by breathing problems, whereas when analysing 29 responses for the SOHO abstract, we found the most important side effect to be risk of long-term cardiovascular problems, followed by fatigue and breathing problems. Take a look at our posters below.