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This is a list of scientific publications on pediatric CML. If you are aware about additional publications, please send us an email - we would be delighted to make our list more complete! THANK YOU!
Complete Cytogenetic Response
Absence of cells with the Philadelphia Chromosome in the bone marrow, usually detected by cytogenetics or FISH diagnostics
Complete Hematologic Response
The blood cell count has returned to normal, and tests don’t show any immature white blood cells. Also, the spleen has returned to a normal size if it was enlarged.
Partial Cytogenetic Response
Between 1-35% of all cells still have the Philadelphia chromosome
Minimal residual disease
A type of deep remission in CML where BCR-ABL is however still detectable by PCR
Chronic Myeloid Leukemia
also called: Chronic Myelogeneous Leukemia
A chronic disease of the blood and bone marrow that results from a transformation of a stem cell.
Philadelphia chromosome
A certain change in chromosomes (on chromosome 22) found in 95% of patients who have CML. The Philadelphia chromosome results from a mutation that involves the fusion of parts of chromosome 9 and chromosome 22 (the bcr-abl fusion gene)
Progressive disease
Disease with a worsening course
First-line therapy
The first treatment given after a disease has been diagnosed. Patients who do not respond to or do not tolerate this treatment, will receive second-line therapy.
Also called induction therapy or primary treatment.
Pleural effusion
The accumulation of fluid in the fluid-filled space that surrounds the lungs
haematological
Relating to blood or the formation of blood
Also called: hematological
Chronic phase
The earliest phase of CML development.
Proliferation
Multiplication of cells
Response rate
Proportion of patients (in percent) in whom a specific therapy led to a decrease in or disappearance of signs and symptoms of a disease.
Adverse event
An undesired or unintended occurrence or side effect that has a temporal relationship with the use of a medical treatment or procedure in a clinical study. An adverse event does not necessarily have a causal relationship with the study treatment.
Also called: AE
Blast crisis
The third phase of development of CML after chronic and accelerated phases. It is characterized by the presence of increasing numbers of immature blood cells ("blasts") in the blood and bone marrow.
Intermittent
With interruptions, at intervals
Chemotherapy
Chemotherapy is the use of drugs to treat cancer by destroying or slowing the growth of fast-growing cancer cells. The term chemotherapy also includes treatment with antibiotics.
Splenomegaly
Enlargement of the spleen. A number of diseases which are related to the immune system is associated with splenomegaly. This includes leukemias. A normal-sized spleen cannot be palpated (felt) during the physical examination of the abdomen, except in slender people. An enlarged spleen is usually palpable during careful physical examination.
Progression
Worsening of a cancer
Side effect
Adverse effects of a treatment:, side effects limit the maximum tolerable dose in particular during chemotherapy.
Resistance
The ability to withstand the effects of a drug, e.g. resistance of cancer cells to a specific therapy.
Compliance
Willingness of a patient to reliably adhere to treatment measures and follow medical instructions.
Chromosome
A chromosome is a structure of DNA that carries the genetic makeup in the nucleus of the cell. Chromosomes contain giant chain molecules of DNA, coiled and folded as aggregates with specific proteins. Chromosomes ensure that during cell division the hereditary information is evenly distributed to the daughter cells. Normal human body cells have 46 chromosomes. Cancer cells can have a different number and/or structure of chromosomes.
Autologous
Derived or transferred from the same individual (e.g. autologous bone marrow transplant), where donor and recipient are the same person.
Allogeneic
Being genetically different although belonging to or obtained from the same species, e.g. allogeneic stem cell transplantation.
Autologous
Derived or transferred from the same individual (e.g. autologous bone marrow transplant), where donor and recipient are the same person.
Stem cells
Stem cells are cells that have the potential to develop into many different types of cell in the body including red blood cells (erythrocytes), white blood cells (leukocytes) as well as platelets (thrombocytes). Stem cells are formed in bone marrow and also in blood.
Stem cells usually come from two main sources: embryos and adult tissue. Embryonic stem cells can multiply and differentiate and ultimately form the entire organism whereas adult stem cells are generally thought to have limited ability to differentiate based on their tissue of origin. They are able to regenerate cells from their original organ.
Indication
In medicine, a reason to use a certain diagnostic test, therapeutic procedure or medication. The opposite of indication is contraindication.
Incidence
The number of new cases of a specific disease occurring during a certain period, e.g. one year
Histology
The study of the structure, composition and function of the body tissues
Dasatinib
Trade name: Sprycel, development name: BMS-354825, inhibits BCR-ABL and SRC tyrosine kinases. Authorized for marketing in the EU since 2006 for the treatment of CML and Ph+ALL.
Other names: BMS-354825|BMS354825|Sprycel
Fertility
Capacity to produce offspring (to conceive or induce conception)
Morbidity
The incidence of a disease in a population.
Toxicity
The quality of being poisonous; harm resulting from drugs, e.g. side effects of chemotherapy.
Imatinib
Imatinib, trade name Glivec/Gleevec, development name STI-571, a first-generation BCR-ABL tyrosine kinase inhibition. Authorized for marketing since 2002 for the treatment of CML and Ph-positive ALL.
Other names: Gleevec|Glivec
Curative
Disappearance of the disease and return to a “normal” healthy state.
Receptor
Binding site for signaling substances; e.g. hormone receptor
BCR-ABL
The abnormal gene that characterizes Chronic Myeloid Leukemia, which is a fusion of the BCR gene of chromosome 9 and the ABL gene of chromosome 22
Chronic
Long-lasting, slowly developping
Symptom
A sign of disease or disorder (Greek; accident, happening)
Blast
An immature white blood cell that normally represents an early phase of the development process of a blood stem cell in the bone marrow
Acute
Of sudden onset, severe; of short duration.
Onco-
Part of the term oncology (study and science dealing with cancer).
FISH
Abbreviated "Fluorescence In Situ Hybridization", a specific diagnostic test to detect genetic changes in chromosomes, like the BCR-ABL gene
TKIs
Tyrosine Kinase Inhibitors, a class of drugs that block an enzyme involved in the mechanism of division of cells
CCyR
Abbreviation for Complete Cytogenetic Response, which is the absence of cells with the Philadelphia Chromosome in the bone marrow, usually detected by cytogenetics or FISH diagnostics
Gene
A unit of information present as DNA; a gene usually contains the blueprint for a protein.
Oral
Oral, pertaining to the mouth; taken through or applied in the mouth.
CML
Chronic Myeloid Leukemia, also called Chronic Myelogenous Leukemia
A chronic disease of the blood and bone marrow that results from a transformation of a stem cell.
BMT
Bone Marrow Transplant
SCT
Stem Cell Transplant
ASH
American Society of Hematology
HLA
Human Leukocyte Antigen - the proteins on the surface of all cells that must be matched for bone/stem cell transplants to avoid immune reactions of the donor's immune system against the body of the recipient
PCR
Polymerase Chain Reaction, a very sensitive diagnostic test that allows the detection of certain genes (DNA) on a very sensitive level. PCR can detect up to one single gene in about 1 million genes.
MMR
Major Molecular Response (MMR), a level of response to CML therapy where the BCR-ABL ratio is equal or below 0,1%
CMR
Complete molecular response means undetectable residual disease on a certain molecular test. Given "completeness" of response depends also on the sensitivity of the CML diagnostics used, this term has been replaced my MR4, MR4.5, which states a molecular remission with a reduction of residual disease below a given level.
Ph+
Abbreviation for "Philadelphia-Chromosome-positive", meaning the presence of a certain change in chromosomes (on chromosome 22) found in 95% of patients who have CML. The Philadelphia chromosome results from a mutation that involves the fusion of parts of chromosome 9 and chromosome 22 (the bcr-abl fusion gene).
CHR
Abbreviation for Complete Hematologic Response. The blood cell count has returned to normal, and tests don’t show any immature white blood cells. Also, the spleen has returned to a normal size if it was enlarged.
GUS
ß-glucuronidase; an enzyme
CAM
Complementary and Alternative Medicine
BID
Twice a day (Latin: bis in die)
APL
Acute promyelocytic leukemia; a subtype of acute myelogenous leukemia (AML)
Complete Cytogenetic Response
Absence of cells with the Philadelphia Chromosome in the bone marrow, usually detected by cytogenetics or FISH diagnostics
Complete Hematologic Response
The blood cell count has returned to normal, and tests don’t show any immature white blood cells. Also, the spleen has returned to a normal size if it was enlarged.
Partial Cytogenetic Response
Between 1-35% of all cells still have the Philadelphia chromosome
Minimal residual disease
A type of deep remission in CML where BCR-ABL is however still detectable by PCR
Chronic Myeloid Leukemia
also called: Chronic Myelogeneous Leukemia
A chronic disease of the blood and bone marrow that results from a transformation of a stem cell.
Philadelphia chromosome
A certain change in chromosomes (on chromosome 22) found in 95% of patients who have CML. The Philadelphia chromosome results from a mutation that involves the fusion of parts of chromosome 9 and chromosome 22 (the bcr-abl fusion gene)
Progressive disease
Disease with a worsening course
First-line therapy
The first treatment given after a disease has been diagnosed. Patients who do not respond to or do not tolerate this treatment, will receive second-line therapy.
Also called induction therapy or primary treatment.
Pleural effusion
The accumulation of fluid in the fluid-filled space that surrounds the lungs
haematological
Relating to blood or the formation of blood
Also called: hematological
Chronic phase
The earliest phase of CML development.
Proliferation
Multiplication of cells
Response rate
Proportion of patients (in percent) in whom a specific therapy led to a decrease in or disappearance of signs and symptoms of a disease.
Adverse event
An undesired or unintended occurrence or side effect that has a temporal relationship with the use of a medical treatment or procedure in a clinical study. An adverse event does not necessarily have a causal relationship with the study treatment.
Also called: AE
Blast crisis
The third phase of development of CML after chronic and accelerated phases. It is characterized by the presence of increasing numbers of immature blood cells ("blasts") in the blood and bone marrow.
Intermittent
With interruptions, at intervals
Chemotherapy
Chemotherapy is the use of drugs to treat cancer by destroying or slowing the growth of fast-growing cancer cells. The term chemotherapy also includes treatment with antibiotics.
Splenomegaly
Enlargement of the spleen. A number of diseases which are related to the immune system is associated with splenomegaly. This includes leukemias. A normal-sized spleen cannot be palpated (felt) during the physical examination of the abdomen, except in slender people. An enlarged spleen is usually palpable during careful physical examination.
Progression
Worsening of a cancer
Side effect
Adverse effects of a treatment:, side effects limit the maximum tolerable dose in particular during chemotherapy.
Resistance
The ability to withstand the effects of a drug, e.g. resistance of cancer cells to a specific therapy.
Compliance
Willingness of a patient to reliably adhere to treatment measures and follow medical instructions.
Chromosome
A chromosome is a structure of DNA that carries the genetic makeup in the nucleus of the cell. Chromosomes contain giant chain molecules of DNA, coiled and folded as aggregates with specific proteins. Chromosomes ensure that during cell division the hereditary information is evenly distributed to the daughter cells. Normal human body cells have 46 chromosomes. Cancer cells can have a different number and/or structure of chromosomes.
Autologous
Derived or transferred from the same individual (e.g. autologous bone marrow transplant), where donor and recipient are the same person.
Allogeneic
Being genetically different although belonging to or obtained from the same species, e.g. allogeneic stem cell transplantation.
Autologous
Derived or transferred from the same individual (e.g. autologous bone marrow transplant), where donor and recipient are the same person.
Stem cells
Stem cells are cells that have the potential to develop into many different types of cell in the body including red blood cells (erythrocytes), white blood cells (leukocytes) as well as platelets (thrombocytes). Stem cells are formed in bone marrow and also in blood.
Stem cells usually come from two main sources: embryos and adult tissue. Embryonic stem cells can multiply and differentiate and ultimately form the entire organism whereas adult stem cells are generally thought to have limited ability to differentiate based on their tissue of origin. They are able to regenerate cells from their original organ.
Indication
In medicine, a reason to use a certain diagnostic test, therapeutic procedure or medication. The opposite of indication is contraindication.
Incidence
The number of new cases of a specific disease occurring during a certain period, e.g. one year
Histology
The study of the structure, composition and function of the body tissues
Dasatinib
Trade name: Sprycel, development name: BMS-354825, inhibits BCR-ABL and SRC tyrosine kinases. Authorized for marketing in the EU since 2006 for the treatment of CML and Ph+ALL.
Other names: BMS-354825|BMS354825|Sprycel
Fertility
Capacity to produce offspring (to conceive or induce conception)
Morbidity
The incidence of a disease in a population.
Toxicity
The quality of being poisonous; harm resulting from drugs, e.g. side effects of chemotherapy.
Imatinib
Imatinib, trade name Glivec/Gleevec, development name STI-571, a first-generation BCR-ABL tyrosine kinase inhibition. Authorized for marketing since 2002 for the treatment of CML and Ph-positive ALL.
Other names: Gleevec|Glivec
Curative
Disappearance of the disease and return to a “normal” healthy state.
Receptor
Binding site for signaling substances; e.g. hormone receptor
BCR-ABL
The abnormal gene that characterizes Chronic Myeloid Leukemia, which is a fusion of the BCR gene of chromosome 9 and the ABL gene of chromosome 22
Chronic
Long-lasting, slowly developping
Symptom
A sign of disease or disorder (Greek; accident, happening)
Blast
An immature white blood cell that normally represents an early phase of the development process of a blood stem cell in the bone marrow
Acute
Of sudden onset, severe; of short duration.
Onco-
Part of the term oncology (study and science dealing with cancer).
FISH
Abbreviated "Fluorescence In Situ Hybridization", a specific diagnostic test to detect genetic changes in chromosomes, like the BCR-ABL gene
TKIs
Tyrosine Kinase Inhibitors, a class of drugs that block an enzyme involved in the mechanism of division of cells
CCyR
Abbreviation for Complete Cytogenetic Response, which is the absence of cells with the Philadelphia Chromosome in the bone marrow, usually detected by cytogenetics or FISH diagnostics
Gene
A unit of information present as DNA; a gene usually contains the blueprint for a protein.
Oral
Oral, pertaining to the mouth; taken through or applied in the mouth.
CML
Chronic Myeloid Leukemia, also called Chronic Myelogenous Leukemia
A chronic disease of the blood and bone marrow that results from a transformation of a stem cell.
BMT
Bone Marrow Transplant
SCT
Stem Cell Transplant
ASH
American Society of Hematology
HLA
Human Leukocyte Antigen - the proteins on the surface of all cells that must be matched for bone/stem cell transplants to avoid immune reactions of the donor's immune system against the body of the recipient
PCR
Polymerase Chain Reaction, a very sensitive diagnostic test that allows the detection of certain genes (DNA) on a very sensitive level. PCR can detect up to one single gene in about 1 million genes.
MMR
Major Molecular Response (MMR), a level of response to CML therapy where the BCR-ABL ratio is equal or below 0,1%
CMR
Complete molecular response means undetectable residual disease on a certain molecular test. Given "completeness" of response depends also on the sensitivity of the CML diagnostics used, this term has been replaced my MR4, MR4.5, which states a molecular remission with a reduction of residual disease below a given level.
Ph+
Abbreviation for "Philadelphia-Chromosome-positive", meaning the presence of a certain change in chromosomes (on chromosome 22) found in 95% of patients who have CML. The Philadelphia chromosome results from a mutation that involves the fusion of parts of chromosome 9 and chromosome 22 (the bcr-abl fusion gene).
CHR
Abbreviation for Complete Hematologic Response. The blood cell count has returned to normal, and tests don’t show any immature white blood cells. Also, the spleen has returned to a normal size if it was enlarged.
GUS
ß-glucuronidase; an enzyme
CAM
Complementary and Alternative Medicine
BID
Twice a day (Latin: bis in die)
APL
Acute promyelocytic leukemia; a subtype of acute myelogenous leukemia (AML)
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Complete Cytogenetic Response
Absence of cells with the Philadelphia Chromosome in the bone marrow, usually detected by cytogenetics or FISH diagnostics
Complete Hematologic Response
The blood cell count has returned to normal, and tests don’t show any immature white blood cells. Also, the spleen has returned to a normal size if it was enlarged.
Partial Cytogenetic Response
Between 1-35% of all cells still have the Philadelphia chromosome
Minimal residual disease
A type of deep remission in CML where BCR-ABL is however still detectable by PCR
Chronic Myeloid Leukemia
also called: Chronic Myelogeneous Leukemia
A chronic disease of the blood and bone marrow that results from a transformation of a stem cell.
Philadelphia chromosome
A certain change in chromosomes (on chromosome 22) found in 95% of patients who have CML. The Philadelphia chromosome results from a mutation that involves the fusion of parts of chromosome 9 and chromosome 22 (the bcr-abl fusion gene)
Progressive disease
Disease with a worsening course
First-line therapy
The first treatment given after a disease has been diagnosed. Patients who do not respond to or do not tolerate this treatment, will receive second-line therapy.
Also called induction therapy or primary treatment.
Pleural effusion
The accumulation of fluid in the fluid-filled space that surrounds the lungs
haematological
Relating to blood or the formation of blood
Also called: hematological
Chronic phase
The earliest phase of CML development.
Proliferation
Multiplication of cells
Response rate
Proportion of patients (in percent) in whom a specific therapy led to a decrease in or disappearance of signs and symptoms of a disease.
Adverse event
An undesired or unintended occurrence or side effect that has a temporal relationship with the use of a medical treatment or procedure in a clinical study. An adverse event does not necessarily have a causal relationship with the study treatment.
Also called: AE
Blast crisis
The third phase of development of CML after chronic and accelerated phases. It is characterized by the presence of increasing numbers of immature blood cells ("blasts") in the blood and bone marrow.
Intermittent
With interruptions, at intervals
Chemotherapy
Chemotherapy is the use of drugs to treat cancer by destroying or slowing the growth of fast-growing cancer cells. The term chemotherapy also includes treatment with antibiotics.
Splenomegaly
Enlargement of the spleen. A number of diseases which are related to the immune system is associated with splenomegaly. This includes leukemias. A normal-sized spleen cannot be palpated (felt) during the physical examination of the abdomen, except in slender people. An enlarged spleen is usually palpable during careful physical examination.
Progression
Worsening of a cancer
Side effect
Adverse effects of a treatment:, side effects limit the maximum tolerable dose in particular during chemotherapy.
Resistance
The ability to withstand the effects of a drug, e.g. resistance of cancer cells to a specific therapy.
Compliance
Willingness of a patient to reliably adhere to treatment measures and follow medical instructions.
Chromosome
A chromosome is a structure of DNA that carries the genetic makeup in the nucleus of the cell. Chromosomes contain giant chain molecules of DNA, coiled and folded as aggregates with specific proteins. Chromosomes ensure that during cell division the hereditary information is evenly distributed to the daughter cells. Normal human body cells have 46 chromosomes. Cancer cells can have a different number and/or structure of chromosomes.
Autologous
Derived or transferred from the same individual (e.g. autologous bone marrow transplant), where donor and recipient are the same person.
Allogeneic
Being genetically different although belonging to or obtained from the same species, e.g. allogeneic stem cell transplantation.
Autologous
Derived or transferred from the same individual (e.g. autologous bone marrow transplant), where donor and recipient are the same person.
Stem cells
Stem cells are cells that have the potential to develop into many different types of cell in the body including red blood cells (erythrocytes), white blood cells (leukocytes) as well as platelets (thrombocytes). Stem cells are formed in bone marrow and also in blood.
Stem cells usually come from two main sources: embryos and adult tissue. Embryonic stem cells can multiply and differentiate and ultimately form the entire organism whereas adult stem cells are generally thought to have limited ability to differentiate based on their tissue of origin. They are able to regenerate cells from their original organ.
Indication
In medicine, a reason to use a certain diagnostic test, therapeutic procedure or medication. The opposite of indication is contraindication.
Incidence
The number of new cases of a specific disease occurring during a certain period, e.g. one year
Histology
The study of the structure, composition and function of the body tissues
Dasatinib
Trade name: Sprycel, development name: BMS-354825, inhibits BCR-ABL and SRC tyrosine kinases. Authorized for marketing in the EU since 2006 for the treatment of CML and Ph+ALL.
Other names: BMS-354825|BMS354825|Sprycel
Fertility
Capacity to produce offspring (to conceive or induce conception)
Morbidity
The incidence of a disease in a population.
Toxicity
The quality of being poisonous; harm resulting from drugs, e.g. side effects of chemotherapy.
Imatinib
Imatinib, trade name Glivec/Gleevec, development name STI-571, a first-generation BCR-ABL tyrosine kinase inhibition. Authorized for marketing since 2002 for the treatment of CML and Ph-positive ALL.
Other names: Gleevec|Glivec
Curative
Disappearance of the disease and return to a “normal” healthy state.
Receptor
Binding site for signaling substances; e.g. hormone receptor
BCR-ABL
The abnormal gene that characterizes Chronic Myeloid Leukemia, which is a fusion of the BCR gene of chromosome 9 and the ABL gene of chromosome 22
Chronic
Long-lasting, slowly developping
Symptom
A sign of disease or disorder (Greek; accident, happening)
Blast
An immature white blood cell that normally represents an early phase of the development process of a blood stem cell in the bone marrow
Acute
Of sudden onset, severe; of short duration.
Onco-
Part of the term oncology (study and science dealing with cancer).
FISH
Abbreviated "Fluorescence In Situ Hybridization", a specific diagnostic test to detect genetic changes in chromosomes, like the BCR-ABL gene
TKIs
Tyrosine Kinase Inhibitors, a class of drugs that block an enzyme involved in the mechanism of division of cells
CCyR
Abbreviation for Complete Cytogenetic Response, which is the absence of cells with the Philadelphia Chromosome in the bone marrow, usually detected by cytogenetics or FISH diagnostics
Gene
A unit of information present as DNA; a gene usually contains the blueprint for a protein.
Oral
Oral, pertaining to the mouth; taken through or applied in the mouth.
CML
Chronic Myeloid Leukemia, also called Chronic Myelogenous Leukemia
A chronic disease of the blood and bone marrow that results from a transformation of a stem cell.
BMT
Bone Marrow Transplant
SCT
Stem Cell Transplant
ASH
American Society of Hematology
HLA
Human Leukocyte Antigen - the proteins on the surface of all cells that must be matched for bone/stem cell transplants to avoid immune reactions of the donor's immune system against the body of the recipient
PCR
Polymerase Chain Reaction, a very sensitive diagnostic test that allows the detection of certain genes (DNA) on a very sensitive level. PCR can detect up to one single gene in about 1 million genes.
MMR
Major Molecular Response (MMR), a level of response to CML therapy where the BCR-ABL ratio is equal or below 0,1%
CMR
Complete molecular response means undetectable residual disease on a certain molecular test. Given "completeness" of response depends also on the sensitivity of the CML diagnostics used, this term has been replaced my MR4, MR4.5, which states a molecular remission with a reduction of residual disease below a given level.
Ph+
Abbreviation for "Philadelphia-Chromosome-positive", meaning the presence of a certain change in chromosomes (on chromosome 22) found in 95% of patients who have CML. The Philadelphia chromosome results from a mutation that involves the fusion of parts of chromosome 9 and chromosome 22 (the bcr-abl fusion gene).
CHR
Abbreviation for Complete Hematologic Response. The blood cell count has returned to normal, and tests don’t show any immature white blood cells. Also, the spleen has returned to a normal size if it was enlarged.
GUS
ß-glucuronidase; an enzyme
CAM
Complementary and Alternative Medicine
BID
Twice a day (Latin: bis in die)
APL
Acute promyelocytic leukemia; a subtype of acute myelogenous leukemia (AML)
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